187 Prevalence of metabolic syndrome (ms) in patients with systemic lupus erythematosus (sle) in mexican population and its relationship with inflammation markers. multicenter study

Abstract

Results 87 patients (82 females) had mean age 29.23 ±13.13SD (6 -62) at TB infection, mean SLE disease duration 3.40±4.44SD (<1-23) years. There were 59 (67%) PTB, 5 (6%) EPTB, 23 (27%) DTB. Extra-pulmonary sites included 8 meningitis or brain abscess, 7 soft tissue abscess, 7 pleural effusion, 3 genitourinary, 3 arthritis, 1 hepatobiliary, 1 ileocecal, 1 cutaneous. Average SLEDAI score was 4. , nephritis in 31 (35.63%). Average cumulative prednisone was 15.29±19.38SD (0.5-86.4) grams; mean daily prednisone was 13.87+10.5SD mg (0 -50) with 22 patients (25.29%) taking immunosuppressives 3 months preceding TB. Significant risks for DTB were nephritis (p=0.017) and prednisone >11 mg/d (p<0.05). Sixty three (72.41%) successfully completed anti-TB treatment. Among 24 deaths, 9 were attributed to TB (6 disseminated, 3 PTB respiratory failure), 15 due to active lupus. Conclusions In this cohort, nephritis and recent prednisone dose >11 mg/day were significant risk factors for disseminated TB which is associated with poor prognosis. Background and aims Patients with systemic lupus erythematosus (SLE) and antiphospholipidsyndrome (APS) are at increased risk of atherosclerosis, and occurs much earlier compared to the general population even after accounting for traditional risk factors. Aim of the work: To examine the association between serum TWEAK, leptin and subclinical atherosclerosis in SLE and APS. Patients and methods Serum tumour necrosis factor (TNF)-like weak inducer of apoptosis(TWEAK) and leptin were measured in 30 SLE patients, 26 SLE patients with secondary APS(SLE-APS), 14 with primary APS (pAPS) and 20 age and sex matched control. The SLE diseaseactivity index (SLEDAI) was assessed in SLE patients. The intima media thickness (IMT) was measuredby carotid ultrasound. Results Serum TWEAK was significantly higher in patients with pAPS (945.1±16.2 pg/ml) than in SLE-APS (755.3 ±59.9 pg/ml), SLE patients (499.2±47.1 pg/ml) and control (129.6±18.6 pg/ml) (p<0.001). Also, serum leptin was significantly higher in pAPSpatients (14.0±2.8 ng/ml) compared to that in SLE-APS (6.5±0.9 ng/ml), SLE patients (3.8±1.2 ng/ ml) and control (1.6±0.6 ng/ml) (p<0.001). The IMT was significantly increasedin the pAPS patients compared to SLE-APS group (p<0.001), SLE patients (p=0.006) and to the control (p<0.001). A significant correlation was found between TWEAK with the body massindex and high density lipoprotein in SLE-APS and inversely with the random blood sugar and thediastolic blood pressure in SLE patients. Serum leptin only significantly correlated with the totalleucocytic count in SLE patients. Background and aims Systemic lupus erythematosus is a common autoimmune disease occurring predominantly in women. Anaemia is common in SLE patients, the most commom cause of anaemia is anaemia of chronic disease. The key mediator of anaemia of chronic disease is Hepcidin.The aim of this study was to determine the role of hepcidin in anaemia of chronic disease in SLE and its role in differentiation between ACD and IDA. Methods The ...