186: The anti-cancer effects of clioquinol on oral cancer

Lee, M.W.; Lin, P.C.; Tsai, WY

doi:10.1016/s0959-8049(14)50159-1

European Journal of Cancer

2014

DOI: 10.1016/s0959-8049(14)50159-1

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186: The anti-cancer effects of clioquinol on oral cancer

M.W. Lee¹,

P.C. Lin²,

WY Tsai³

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“…Owing to its ability to bind copper/zinc and dissolve beta-amyloid plaques by activating autophagy in the brain, clioquinol has re-emerged as a potential therapy for Alzheimer's disease (6,7). Clioquinol was also reported to have anticancer activity in several carcinoma cells (8)(9)(10)(11). Especially, in preclinical models of hematologic malignancies and solid tumors, clioquinol displays anticancer efficacy in vitro and in vivo (12)(13)(14).…”

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Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol

et al. 2015

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Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinolClioquinol has been shown to have anticancer activity in several carcinoma cells. In this study, we preliminarily examined the effect of clioquinol in human SMMC-7721 hepatoma and QSG-7701 normal hepatic cells. Our results indicated that clioquinol did not significantly affect survival of QSG-7701 cells, whereas it reduced cell viability in a concentration-and time-dependent manner in SMMC-7721 cells. Clioquinol did not trigger autophagy and apoptosis, while it induced cell cycle arrest in the S-phase in SMMC-7721 cells. Additionally, down-regulation of cyclin D1, A2, E1, Cdk2 and up-regulation of p21, p27 were detected after the treatment with clioquinol. The results demonstrated for the first time that clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 cells via the p21, p27-cyclin E,A/Cdk2 pathway. This suggests that clioquinol may have a therapeutic potential as an anticancer drug for certain malignances.

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confidence: 99%

Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol

et al. 2015

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186: The anti-cancer effects of clioquinol on oral cancer

Cited by 1 publication

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Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol

Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol

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