183: Multisystem Inflammatory Syndrome in Pennsylvania: The Intersection of Adult and Pediatric Care

The Impact of COVID-19 on the Cardiovascular Health of Emerging Adults Aged 18-25: Findings From a Scoping Review

“…In this review, 47 cases (mean age=21; 70% male) of emerging adults with cardiovascular complications in the context of confirmed or suspected hyperinflammatory syndromes and active or previous COVID-19 were identified. 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 If not concomitant COVID-19, previous infections typically occurred 3-8 weeks prior to onset of symptoms. 23 , 30 , 32 , 33 , 34 , 40 , 43 , 44 , 45 , 46 , 52 , 53 , 56 Alongside MIS-C/A, cardiovascular presentations/complications included ventricular dysfunction (n=33), tachycardia (n=28), hypotension (n=16), cardiogenic shock (n=14), cardiomyopathy (n=11), including myocarditis and pericarditis, valve insufficiency (n=4), atrial fibrillation (n=2), and non-ST-elevation myocardial infarction (n=2); refer to Supplemental Table S2 for additional case details.…”

“… 148 In the cohort study by Belay et al 148 , mainstay treatments for MIS included intravenous immunoglobulin (IVIG) and steroids. Across the 47 cases included in this review 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 70% (n=33) were treated with steroids (e.g. methylprednisolone, prednisolone, prednisone) and 62% (n=29) with IVIG.…”