1820P Taxane-related skin toxicity: Analysis of an in vivo and 3D in vitro model study of the impact of paclitaxel on skin

Abstract

Background: Patients with cancer are predisposed to develop CVD. This real-world, population-based study aimed to assess the factors related with new onset CVD in cancer survivors. Methods:We identified patients with stage I-III solid organ cancer in a large Canadian province from 2004 to 2017. Patients with a CVD prior to their cancer diagnosis were excluded. We linked administrative data sources to identify new onset CVD (cardiac arrhythmias, cerebrovascular accidents [CVAs], congestive heart failure [CHF], and myocardial infarctions [MIs]). We performed logistic regression analyses to examine the associations of clinical variables with the development of CVD.