181P Male breast cancer (MBC): Familial history (FH), clinicopathological (CP) characteristics, oncogenetic (OG) testing and outcome in a cohort of 98 patients (pts)

Chrétien, Sebastian; Aymes, E.; Barthoulot, M.; Deley, M. Le; Boulaire, Manon; Oca, Florine; Becourt, Stéphanie; Mailliez, Audrey

doi:10.1016/j.esmoop.2023.101458

Cited by 1 publication

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“…Additionally, various breast biopsy methods such as fine needle aspiration (FNA) to differentiate malignant from non-malignant type of breast disease in men, 115 core needle biopsy (CNB), surgical biopsy, and lymph node biopsy can also be employed. However, identification of specific markers those associated with MBC via., molecular profiling could pave way to discover and/or identify newer therapeutic strategies.…”

Section: Ductal Carcinoma In Situ (Dcis)mentioning

confidence: 99%

Male Breast Cancer: Current Scenario and Future Perspectives

Chidambaram,

Prabhakaran,

Sivasamy

et al. 2024

Technol Cancer Res Treat

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Male breast cancer (MBC), one of the rare types of cancer among men where the global incidence rate is 1.8% of all breast cancers cases with a yearly increase in a pace of 1.1%. Since the last 10 years, the incidence has been increased from 7.2% to 10.3% and the mortality rate was decreased from 11% to 3.8%. Nevertheless, the rate of diagnoses has been expected to be around 2.6% in the near future, still there is a great lack in studies to characterize the MBC including the developed countries. Based on our search, it is evidenced from the literature that the number of risk factors for the cause of MBC are significant, which includes the increase in age, family genetic history, mutations in specific genes due to various environmental impacts, hormonal imbalance and unregulated expression receptors for specific hormones of high levels of estrogen or androgen receptors compared to females. MBCs are broadly classified into ductal and lobular carcinomas with further sub-types, with some of the symptoms including a lump or swelling in the breast, redness of flaky skin in the breast, irritation and nipple discharge that is similar to the female breast cancer (FBC). The most common diagnostic tools currently in use are the ultrasound guided sonography, mammography, and biopsies. Treatment modalities for MBC include surgery, radiotherapy, chemotherapy, hormonal therapy, and targeted therapies. However, the guidelines followed for the diagnosis and treatment modalities of MBC are mostly based on FBC that is due to the lack of prospective studies related to MBC. However, there are distinct clinical and molecular features of MBC, it is a need to develop different clinical methods with more multinational approaches to help oncologist to improve care for MBC patients.

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Section: Ductal Carcinoma In Situ (Dcis)mentioning

confidence: 99%