Abstract:Introduction: The liver is particularly susceptible to the detrimental effects of a high fat diet (HFD), and rapidly develops insulin resistance. While the underlying mechanisms associated with hepatic insulin resistance are not fully understood, mitochondria play a crucial role in regulating lipid metabolism and redox balance. Recently, dietary nitrate was shown to attenuate HFD-induced glucose intolerance, however the mechanism(s) remains unknown. Therefore, in the present study we examined the possibility t… Show more
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