180-W XPS GreenLight Laser Vaporisation Versus Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Obstruction: 6-Month Safety and Efficacy Results of a European Multicentre Randomised Trial—The GOLIATH Study

Bachmann, Alexander; Tubaro, Andrea; Barber, Neil; d’Ancona, Frank; Muir, Gordon; Witzsch, U.; Grimm, Marc‐Oliver; Benejam, Joan; Stolzenburg, Jens‐Uwe; Riddick, Antony C. P.; Pahernik, Sascha; Roelink, Herman; Ameye, Filip; Saussine, C.; Bruyère, F.; Loidl, Wolfgang; Larner, Tim; Gogoi, Nirjan-Kumar; Hindley, Richard G.; Muschter, R.; Thorpe, Andrew; Shrotri, Nitin; Graham, Stuart; Hamann, Moritz; Miller, Kurt; Schostak, Martin; Capitán, Carlos; Knispel, Helmut H.; Thomas, James A.

doi:10.1016/j.eururo.2013.10.040

Cited by 195 publications

(149 citation statements)

References 30 publications

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“…Our OT is in line with data published by GOLIATH study with a median OT of 46 min (range 15–160) in GL-XPS and in comparison with a median of 36 min (range 0–160) in TURP [7]. …”

Section: Discussionsupporting

confidence: 80%

“…The GOLIATH study confirmed the non-inferiority of GL-XPS compared to TURP with regard to IPSS, Qmax, and complication rates in 2012 [7-9]. GL-XPS, other than the previous systems with less energy was available since 2010.…”

Section: Introductionmentioning

confidence: 51%

“…Likewise the effective LT could be significantly reduced more than 30% in our 5 year time course and is shorter than the median LT of recent GOLIATH study with median 41 min (range 14–140) and even shorter than recently published data by Gueli et al [12] with an LT of median 55 min comparing prostate volumes >100 mL [7, 12, 14]. …”

Section: Discussionmentioning

confidence: 82%

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Perioperative Changes and Progress in Photoselective Vaporization of the Prostate with GreenLight XPS 180 W System: A Single Center Experience

et al. 2018

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Purpose: The study aimed to evaluate progression of GreenLight-XPS 180 W photoselective vaporization of the prostate (GL-XPS) with respect to effectiveness, efficacy, and safety over time at a tertiary referral high volume center. Methods: The retrospective study included 375 men who underwent GL-XPS for symptomatic benign prostate obstruction (BPO) between June 2010 and February 2015. Primary outcome measurements were operation time (OT; min) and effective laser time (LT; min of OT) analyzed with regard to prostatic volume (PV; mL) (group 1 <40 mL up to 4 >80 mL in 20 mL steps) and the year of surgery (2010–2015). Results: The median age was 72 years (range 64–79), the median PV was 58 mL (range 33–98) and the median PV increased from 42 mL in 2012 to 80 mL in 2015. The OT and LT clearly correlated with the PV, being doubled for glands of median 95 mL compared to median 30 mL while the applied laser energy per LT likewise steadily increased. Overall, both OT and LT could be significantly reduced each year by 37% (OT; p < 0.05) and 36% (LT; p < 0.05) within 5 years. The hospital stay (days) and catheterization time (days) remained constant, without any changes over time. The overall complication rate (Clavien-Dindo >2) ranged from 36 to 15% between 2010 and 2015. The pre (median 22 + 4) and postoperative International Prostate Symptom Score-Quality of Life (median 5 + 1) showed a sufficient reduction in symptomatic BPO. Conclusion: GL-XPS is a safe and effective surgical method for symptomatic BPO. Our single center experience showed a significant improvement of both OT and effective LT within 5 years whilst maintaining stable low complication rate and high patient satisfaction.

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“…Our OT is in line with data published by GOLIATH study with a median OT of 46 min (range 15–160) in GL-XPS and in comparison with a median of 36 min (range 0–160) in TURP [7]. …”

Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 51%

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Perioperative Changes and Progress in Photoselective Vaporization of the Prostate with GreenLight XPS 180 W System: A Single Center Experience

et al. 2018

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“…PVP has the advantage over TURP of using saline as the irrigant, thus almost removing the risk of transurethral resection syndrome. The PVP laser causes minimal surgical trauma, very little bleeding, speedy recovery and only few complications [22,23]. Based on the merits of PVP, we utilize this technique to treat aged and high-risk BPH patients due to BOO who cannot sustain TURP.…”

Section: Discussionmentioning

confidence: 99%

Photoselective Vaporization of the Prostate and Simultaneous Suprapubic Cystostomy for the Treatment of Benign Prostatic Hyperplasia in Patients with Mild to Severe Detrusor Underactivity

Zhao-yi

et al. 2015

Urol Int

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Introduction: This study investigated the clinical efficacy and safety of photoselective vaporization of the prostate (PVP) and simultaneous suprapubic cystostomy for benign prostatic hyperplasia (BPH) in patients with mild to severe detrusor underactivity (DU). Subjects and Methods: Seventy-eight patients with BPH were divided into 3 groups according to the severity of DU: mild DU group, moderate DU group and severe DU group. The preoperative and postoperative data, including the detrusor pressure at maximum flow (Pdet_max), bladder compliance, maximum urinary flow (Q_max), postvoid residual urine (PVR) values, International Prostate Symptom Score (IPSS) and quality of life (QoL) were evaluated. Results: The therapeutic effectiveness including cure and improvement in mild and moderate DU group was significantly higher than that of the severe group. Compared to the preoperative values, Pdet_max, bladder compliance, Q_max, PVR, IPSS and QoL scores at 12 months postoperatively had significantly improved. In addition, the above parameters at 12 months postoperatively in the mild or moderate DU group had significant difference compared to the severe DU group. Conclusion: PVP and simultaneous suprapubic cystostomy seem to be an appropriate treatment modality in BPH patients with mild and/or moderate DU as well as in patients with severe DU and slightly reduced bladder compliance.

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“…There are several accepted techniques for resection, including laser, which has efficacy equivalent to TURP [1].…”

Section: Introductionmentioning

confidence: 99%

Characterization of men with lower urinary tract dysfunction after surgical management of benign prostatic obstruction

Buck

Dunphy

Lee

et al. 2014

Bladder

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OBJECTIVE:To characterize the symptoms and urodynamic findings of men with lower urinary tract dysfunction after a transurethral resection of the prostate (TURP). MATERIALS AND METHODS:A total of 123 consecutive men with lower urinary tract dysfunction after surgical treatment for lower urinary tract symptoms (LUTS) were analyzed. Men with prostate cancer, stricture, multiple TURPs, radical prostatectomy or prostate cancer treatment were excluded. Parameters assessed by urodynamics included bladder capacity, detrusor contractibility, pressure flow study, and post void residual. Analysis of the variance was used to compare outcomes of urodynamic parameters between the primary diagnoses. RESULTS:Mean age at TURP was 68 years (range 39 to 88). Symptoms included frequency (68%), nocturia (53%), urgency (44%), and retention requiring catheterization (17%). A total of 72 men (59%) were diagnosed with bladder outlet obstruction (BOO), 30 (24%) with impaired detrusor contractility (DU), and 21 (17%) with detrusor over activity (DO). Among these groups, there was no difference in duration of recurrent symptoms, AUA symptom score, Quality of Life score, or prostate size. Maximum flow was significantly less and post-void residual significantly greater in both BOO and DU groups. Bladder capacity was significantly higher in DU. CONCLUSIONS:In the modern era, bladder outlet obstruction was the most common cause of recurrent lower urinary tract dysfunction after surgical management of BPO.

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180-W XPS GreenLight Laser Vaporisation Versus Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Obstruction: 6-Month Safety and Efficacy Results of a European Multicentre Randomised Trial—The GOLIATH Study

Cited by 195 publications

References 30 publications

Perioperative Changes and Progress in Photoselective Vaporization of the Prostate with GreenLight XPS 180 W System: A Single Center Experience

Perioperative Changes and Progress in Photoselective Vaporization of the Prostate with GreenLight XPS 180 W System: A Single Center Experience

Photoselective Vaporization of the Prostate and Simultaneous Suprapubic Cystostomy for the Treatment of Benign Prostatic Hyperplasia in Patients with Mild to Severe Detrusor Underactivity

Characterization of men with lower urinary tract dysfunction after surgical management of benign prostatic obstruction

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