18‐Year‐Old Woman with a Dural Mass

Somerset, Hilary; Wilkinson, C Corbett; Kleinschmidt-DeMasters, B. K.

doi:10.1111/bpa.12012

Cited by 6 publications

(8 citation statements)

References 11 publications

(18 reference statements)

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“…Some authors suggested that the tumor may originate from meningeal fibroblasts metaplasia, others suggested that the tumor may arise from multipotential or perivascular mesenchymal cells or aberrant nests of cartilage forming cells in the dura mater. Traumatic displacement of cartilage is another theory proposed in accordance to existing cases of head trauma presenting with chondroma at the trauma site .…”

Section: Discussionmentioning

confidence: 81%

“…The age of patients reported in the literature ranges from 15 months to 60 years. There is no sex predominance .…”

Section: Discussionmentioning

confidence: 99%

“…Intracranial chondroma is a rare benign tumor with an incidence of 0.2%–0.3% of all the intracranial tumors . They mostly originate from the skull base or bulges into the cranial cavity from nasal sinuses .…”

Section: Discussionmentioning

confidence: 99%

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A 19‐year‐old male with a well‐demarcated parieto‐occipital mass

et al. 2017

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A 19-year-old male was referred for a blurred vision and eyestrain associated with occipital headache for several weeks. Ophthalmologic examination showed left homonymous hemianopia and papilledema on fundoscopy. The CT scan showed a 7 cm diameter lobulated hyperdense mass with calcifications. On MRI, the lesion was hyperintense on T2 and hypointense on T1 weighted images with moderate gadolinium enhancement. The lesion was well demarcated and laid on tentorium. Diffusion weighted imaging did not exhibit restriction (High apparent diffusion coefficient (ADC)). Surrounding brain parenchyma was normal (Figure 1a). The lesion was hypoperfused when compared with normal brain (Figure 1b). MRI spectroscopy (Figure 1c) showed a high choline to creatinine ratio (suggesting high cell membrane turn over) and elevated lipids and NAA. The lesion was totally removed via a right parietal craniotomy. Intraoperatively, the lesion was readily visible at the surface of the brain, firm, with a clear dissection plan. It was inserted on the falx cerebri and the tentorium. Gross examination showed a firm lobulated white lesion (Figure 1d). There was no evidence of hemorrhage or necrosis.

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Section: Discussionmentioning

confidence: 81%

“…The age of patients reported in the literature ranges from 15 months to 60 years. There is no sex predominance .…”

Section: Discussionmentioning

confidence: 99%

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A 19‐year‐old male with a well‐demarcated parieto‐occipital mass

et al. 2017

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“…Osteocartilaginous tumors are exceedingly rare, are usually dural‐based, develop in the skull and only secondarily displace dura and brain . To our knowledge, extraosseous osteoma, chondroma, osteochondroma, mesenchymal chondrosarcoma, osteosarcoma and aneurysmal bone cyst have been seldom described in the CNS. A few cases of unusual dura‐based periosteal osteoblastoma have also been reported in cranial bones, such as temporal bone and frontal cranial bone .…”

Section: Discussionmentioning

confidence: 99%

Intraspinal dural‐based primary osteoblastoma with aneurysmal bone cyst‐like change

Jiang

Luo

et al. 2014

Neuropathology

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Osteoblastoma is a benign bone-forming neoplasm that occurs commonly in the posterior elements of the spine and the sacrum. However, so far there has been no report of intradural osteoblastoma described in the literature. We present a unique case of intraspinal dural-based osteoblastoma with aneurysmal bone cyst-like change without evidence of vertebral involvement. An 11-year-old Chinese girl presented with a 3-month history of gradually progressive back pain and a weakness of both lower limbs. Thoracic MRI revealed a well-demarcated subdural mass at the T5 level with heterogeneous enhancement. Histologically, the tumor was found to be attached to the dura and composed of numerous osteoid spicules and trabecular bone with diffusely scattered osteoclast-type, multinucleated giant cells. Ectactic blood vessels and blood-filled cystic spaces were also observed. A diagnosis of primary intraspinal dural-based osteoblastoma with aneurysmal bone cyst-like change was made. To our best knowledge, this is possibly the first case of primary osteoblastoma arising from meninges. Meningeal osteocartilaginous tumors are rare, with obscure histogenesis. The differential diagnosis of osteoblastoma in unusual locations is difficult and the confirmation of diagnosis should be cautiously made. Awareness of dural-based osteoblastoma and its histological features is important to avoid a diagnostic pitfall caused by histological similarities to other intra-craniospinal lesions with osteoid differentiation or bone formation.

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“…Primary intracranial chondrosarcomas are rare, representing <0.15% of all intracranial tumors. Most of them arise from underlying precursor cartilaginous or bony lesions of the axial skeleton, and the most common type of intracranial chondrosarcoma is the mesenchymal type [3,4]. Primary intracranial chondrosarcomas may present with radiation sarcoma [5].…”

Section: Introductionmentioning

confidence: 99%

Squash Cytology of a Dural-Based High-Grade Chondrosarcoma May Mimic That of Glioblastoma in the Central Nervous System

Lee

Kim²,

Chung³

et al. 2015

Acta Cytologica

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Background: Intracranial chondrosarcoma is rare, and most cases occur in the skull base. Intradural chondrosarcoma is even rarer. Case: Here, we describe a case of dural chondrosarcoma with a radiation history for nasopharyngeal carcinoma and a radical prostatectomy for prostatic cancer 15 and 8 years earlier, respectively. A 67-year-old man presented with a 3-week memory disturbance and dysarthria. Computed tomography and magnetic resonance images of the brain revealed a dural-based mass in the left temporal area. Under the impression of a glioblastoma, a resection and an intraoperative squash cytology were done. A necrotic dirty background as well as bluish-to-pinkish myxoid stroma were characteristic; the nuclei of highly pleomorphic tumor cells were hyperchromatic to vesicular with an occasional ground-glass appearance. The cytoplasm was of an eosinophilic hyalinized condensed morphology with an occasional granular appearance. Histologically, the lobulated mass was composed of hypercellular lobules of well-differentiated chondrocytes intermixed with anaplastic pleomorphic cells and diagnosed as a conventional grade III chondrosarcoma. These cells were immunoreactive for D2-40, S-100 protein and vimentin. Brain invasion was also found. Conclusion: Albeit rare, dural-based chondrosarcomas should be considered in the differential diagnosis for meningeal tumors, especially in the case of previous radiation therapy.

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18‐Year‐Old Woman with a Dural Mass

Cited by 6 publications

References 11 publications

A 19‐year‐old male with a well‐demarcated parieto‐occipital mass

A 19‐year‐old male with a well‐demarcated parieto‐occipital mass

Intraspinal dural‐based primary osteoblastoma with aneurysmal bone cyst‐like change

Squash Cytology of a Dural-Based High-Grade Chondrosarcoma May Mimic That of Glioblastoma in the Central Nervous System

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