Abstract:The secreted protein Hedgehog (Hh) acts a morphogen, forming a concentration gradient and controlling cell fate decisions in various developmental stages in many animals. In recent years, there has been significant interest in the role that glypicans play in Hh gradient formation and signalling; with various experimental studies demonstrating an effect on Hh transport, Hh stability and downstream transcription factor (CI) activity.Using mathematical modelling and analysis, we investigate the effects glypicans … Show more
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