18 F-FDG PET/CT and contrast-enhanced CT findings of pulmonary cryptococcosis

Wang, Siyun; Chen, Gang; Luo, Dong-Hua; Shao, Dan; Liu, Entao; Sun, Taotao; Wang, Shuxia

doi:10.1016/j.ejrad.2017.02.008

Cited by 27 publications

(26 citation statements)

References 27 publications

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“…Pulmonary cryptococcus involvement can show variable levels of FDG avidity in PET/CT, ranging from mild to pronounced uptake 64 , 65 . The most common presentation is a solitary nodule, and less frequently: scattered nodular, clustered nodular, mass-like and bronchopneumonic patterns 66 . However, pulmonary cryptococcosis can show a similar pattern of FDG uptake to that of lung cancer 67 , 68 .…”

Section: Cryptococcosis and Histoplasmosismentioning

confidence: 99%

FDG-PET/CT of COVID-19 and Other Lung Infections

Eibschutz

Rabiee

Asadollahi

et al. 2022

Seminars in Nuclear Medicine

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While not conventionally used as the first-line modality, [ 18 F]-2-fluoro-2-deoxy-D-glucose (FDG) - positron emission tomography/computed tomography (PET/CT) can identify infection and inflammation both earlier and with higher sensitivity than anatomic imaging modalities [including chest X-ray (CXR), computed tomography (CT), and magnetic resonance imaging (MRI)]. The extent of inflammation and, conversely, recovery within the lungs, can be roughly quantified on FDG-PET/CT using maximum standardized uptake value (SUVmax) values. The Coronavirus disease 2019 (COVID-19) pandemic has highlighted the value of FDG-PET/CT in diagnosis, elucidation of acute pulmonary and extra-pulmonary manifestations, and long-term follow up. Similarly, many other pulmonary infections such as previously documented coronaviruses, Aspergillosis, Blastomycosis, Candidiasis, Coccidioidomycosis, Cryptococcosis, Histoplasmosis, Mucormycosis, and typical/atypical Mycobacterial infections have all been identified and characterized using FDG-PET/CT imaging. The goal of this review is to summarize the actual and potential benefits of FDG-PET/CT in the imaging of COVID-19 and other lung infections. Further research is necessary to determine the best indications and clinical applications of FDG-PET/CT, improve its specificity, and ultimately ascertain how this modality can best be utilized in the diagnostic work up of infectious pathologies.

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Section: Cryptococcosis and Histoplasmosismentioning

confidence: 99%

FDG-PET/CT of COVID-19 and Other Lung Infections

Eibschutz

Rabiee

Asadollahi

et al. 2022

Seminars in Nuclear Medicine

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“…However, the incidence of PC in immunocompetent patients has increased in recent years [ 4 , 5 ]. Radiographically, PC may appear as a solitary nodule or mass, multifocal nodules, pulmonary consolidations, or bronchopneumonia [ 6 , 7 ]. It is difficult to differentiate PC from primary lung cancer, tuberculosis, or metastasis especially when PC presents as a solitary pulmonary nodule.…”

Section: Introductionmentioning

confidence: 99%

The clinical and radiological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients

Ren

Xiao

et al. 2021

BMC Pulm Med

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Background We characterized the clinical features, radiographic characteristics, and response to treatment of immunocompetent and immunocompromised patients with pulmonary cryptococcosis (PC). Methods We retrospectively reviewed the medical records and radiological profiles of patients diagnosed with PC who received surgical resection between May 2015 and November 2020 in a tertiary referral center. Results A total of 21 males and 18 females were included in the study. 23 patients were immunocompetent and 20 out of the 39 were asymptomatic. Immunocompetent patients were diagnosed with PC at a younger age than immunocompromised patients (48.9 vs 57.1 years, P = 0.02). Single nodule pattern was the most frequent lesion pattern (33 out of 39, 84.6%) and right upper lobe was the most common site of location (15 out of 47, 31.9%). The majority of lesions were located peripherally (38 out of 47, 80.9%) and most lesions were 1–2 cm in diameter (30 out of 47, 63.8%). Cavitation was more likely to occur in immunocompromised patients (5 out of 11, 45.5%) than in immunocompetent patients (6 out of 36, 16.7%) (P = 0.04) and there was complete resolution of PC in all patients treated with anti-fungal therapy. Conclusions Immunocompetent patients were diagnosed with PC at a younger age than immunocompromised patients. Single nodule pattern was the most frequent lesion pattern in PC patients. Cavitation was more likely to occur in immunocompromised patients than in immunocompetent patients.

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“…[ 3 4 ] Some studies showed that the most common radiological presentations of pulmonary cryptococcosis were lung nodules and masses that required differentiation from lung cancer. [ 5 6 ] Several studies demonstrated that symptoms of pulmonary cryptococcosis are often untypical and can emulate those of lung cancer including cough and expectoration. [ 7 8 ] Biopsy of suspected pulmonary cryptococcosis from lung nodule or mass can be challenging.…”

Section: Introductionmentioning

confidence: 99%

Extent of Lung Involvement and Serum Cryptococcal Antigen Test in Non-Human Immunodeficiency Virus Adult Patients with Pulmonary Cryptococcosis

Zhu

Luo

Chen

et al. 2018

Chinese Medical Journal

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Background:Serum cryptococcal antigen (CrAg) test is the most used noninvasive method to detect cryptococcal infection. However, false-negative CrAg test is not uncommon in clinical practice. Then, the aim of this study was to investigate the factors associated with false-negative CrAg test among non-human immunodeficiency virus (HIV) adult patients with pulmonary cryptococcosis and its clinical features.Methods:One hundred and fourteen non-HIV adult patients with pulmonary cryptococcosis, proven by biopsy, were retrospectively reviewed. Finally, 85 patients were enrolled; 56 were CrAg positive (CrAg+ group) and 29 were negative (CrAg− group). It was a cross-sectional study. Then, baseline characteristics, underlying diseases, clinical symptoms, laboratory findings, and chest radiological findings were reviewed and analyzed. Chi-square test was used to analyze categorical variable. Odds ratio (OR) was used to measure correlation. Student's t-test was obtained to analyze continuous variable.Results:No difference in baseline characteristics, underlying diseases, clinical symptoms, and laboratory findings were found between two groups (P > 0.05 in all). Nevertheless, diffuse extent lesion was 82.1% in CrAg+ group and 10.3% in CrAg− group (χ2= 40.34, P < 0.001; OR = 39.87).Conclusions:Among patients with limited pulmonary involvement, a negative serum CrAg does not preclude the diagnosis of pulmonary cryptococcosis. However, among patients with extensive pulmonary involvement, serum CrAg is a useful diagnostic tool for pulmonary cryptococcosis. Furthermore, we also noticed that the untypical and mild presentations with extensive pulmonary lesion might be the features of pulmonary cryptococcosis, which needs further investigation.

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18 F-FDG PET/CT and contrast-enhanced CT findings of pulmonary cryptococcosis

Cited by 27 publications

References 27 publications

FDG-PET/CT of COVID-19 and Other Lung Infections

FDG-PET/CT of COVID-19 and Other Lung Infections

The clinical and radiological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients

Extent of Lung Involvement and Serum Cryptococcal Antigen Test in Non-Human Immunodeficiency Virus Adult Patients with Pulmonary Cryptococcosis

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