17β-Hydroxysteroid dehydrogenases—their role in pathophysiology

Vihko, Pirkko; Härkönen, Pirjo; Soronen, Pia; Törn, Svea; Herrala, Annakaisa; Kurkela, Riitta; Pulkka, Anitta E.; Oduwole, Olayiwola; Isomaa, Veli

doi:10.1016/j.mce.2003.11.021

Cited by 59 publications

(36 citation statements)

References 38 publications

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“…The p8 protein codes for a homologue of a bovine chemokine (85). Some genes like estradiol-17␤-dehydrogenase 4 are involved in estrogen biosynthesis and may control cell growth (89). Interestingly, none of the previously defined STAT1-dependent genes were identified in this screen.…”

Section: Methodsmentioning

confidence: 83%

Critical Role for Transcription Factor C/EBP-β in Regulating the Expression of Death-Associated Protein Kinase 1

Gade

Roy

et al. 2008

Molecular and Cellular Biology

102

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Section: Methodsmentioning

confidence: 83%

Critical Role for Transcription Factor C/EBP-β in Regulating the Expression of Death-Associated Protein Kinase 1

Gade

Roy

et al. 2008

Molecular and Cellular Biology

102

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“…17-HSD type 5 is a member of the aldo-keto reductase (AKR) superfamily, and is formally termed AKR1C3. This enzyme is expressed in various peripheral tissues, liver, prostate, and ovary, and has been also detected in prostate and breast carcinoma tissues [26,37,38]. 17-HSD type 5 immunoreactivity was detected in normal mammary gland and breast carcinoma cells in 53% of such cases.…”

Section: Type 5 17-hsdmentioning

confidence: 97%

Biological Roles of Estrogen and Progesterone in Human Endometrial Carcinoma - New developments in potential endocrine therapy for endometrial cancer -

et al. 2007

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Abstract. Endometrial carcinoma is one of the most common female pelvic malignancies. It is well known that uterine endometrial cell proliferation is under the control of both estrogen and progesterone. In this review, results of the recent studies on the biosynthesis and action of estrogen and progestin in normal endometrium and its disorders will be summarized and the new aspects of hormonal therapies in the patients with endometrial carcinoma will be discussed including its future prospectives. We reported that the enzymes responsible for intratumoral estrogen metabolism and biosynthesis are markedly different between human breast and endometrial carcinoma, although both of them are considered "estrogen-dependent malignancies". In addition, the biological significance of Progesterone receptor (PR) isoforms is considered to differ between endometrial and breast carcinomas. Clinical data concerning Hormone replacement therapy (HRT) and estrogen-dependent cancer risk also support these findings. These basic and clinical findings help to understand the biology and provide the new knowledge for prevention, diagnosis and treatment of human endomerial carcinoma. Specific endocrine treatment of endometrial carcinoma should be explored in future, although aromatase inhibitors are the most effective endocrine treatments of estrogen-responsive breast carcinoma. Retinoid, metabolities of vitamin A, and synthetic peroxisome proliferator-activated receptor (PPAR) γ ligands, which have been used for the treatment of insulin resistance in type II diabetes mellitus, may be the important candidates as drugs not only for prevention but also for possible endocrine treatment of endometrial carcinoma.

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“…Although this estrogen is not directly active on estrogen receptors, it becomes active in many tissues after hydrolysis [2,3] and its reduction to active estradiol (E 2 ) by various 17beta-hydroxysteroid dehydrogenases enzymes [4,5]. Several tissues, whose prostate, contain the enzyme machinery required to convert E 1 S to E 2 [6].…”

Section: Introductionmentioning

confidence: 99%

Plasma estrone sulfate assay in men: Comparison of radioimmunoassay, mass spectrometry coupled to gas chromatography (GC–MS), and liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Giton¹,

Caron²,

Bérubé³

et al. 2010

Clinica Chimica Acta

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, et al.. Plasma estrone sulfate assay in men: Comparison of radioimmunoassay, mass spectrometry coupled to gas chromatography (GC-MS), and liquid chromatography-tandem mass spectrometry (LC-MS/MS).: Plasma estrone sulfate assay in men: comparison between four different assay methods. Clinica Chimica Acta, Elsevier, 2010, 411 (17-18) Acknowledgments:The authors thank Dr. Noah Hardy for editing the manuscript. Methods:We simultaneously assayed estrone sulfate in the plasma of one hundred men aged 30-50 years, according to LC-MS/MS, GC-MS after solvolysis of E 1 S, radioimmunoassay after a chromatographic purification step, and a direct RIA commercial kit.Results: Estrone sulfate plasma levels obtained with the first three methods were not significantly different. However, estrone sulfate levels measured by the direct RIA were threefold higher than those obtained by the first three methods. We showed that the excessively high estrone sulfate levels obtained with the direct RIA kit had two origins:interference by high dehydroepiandrosterone sulfate plasma levels in men, and estrone sulfate inaccurate low concentrations in the standards. Conclusion:The LC-MS/MS method can be considered as an optimum option for clinical laboratory. The GC-MS method requires solvolysis to estrone, but allows simultaneous unconjugated steroid measurement. RIA method, with chromatographic purification, is cumbersome, but less expensive. DSL-5400 kit yielded estrone sulfate plasma levels that were too high.Plasma estrone sulfate assay in men: comparison between four different assay methods 3

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17β-Hydroxysteroid dehydrogenases—their role in pathophysiology

Cited by 59 publications

References 38 publications

Critical Role for Transcription Factor C/EBP-β in Regulating the Expression of Death-Associated Protein Kinase 1

Critical Role for Transcription Factor C/EBP-β in Regulating the Expression of Death-Associated Protein Kinase 1

Biological Roles of Estrogen and Progesterone in Human Endometrial Carcinoma - New developments in potential endocrine therapy for endometrial cancer -

Plasma estrone sulfate assay in men: Comparison of radioimmunoassay, mass spectrometry coupled to gas chromatography (GC–MS), and liquid chromatography-tandem mass spectrometry (LC-MS/MS)

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