17β-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein

Horiguchi, Yuka; Araki, Makoto; Motojima, Kiyoto

doi:10.1016/j.bbrc.2008.03.063

Cited by 70 publications

(72 citation statements)

References 18 publications

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“…In contrast, three proteins were demonstrated to be up-regulated in Tg. Hydroxysteroid (17-beta) dehydrogenase 13 (17␤HSD13) is specifically expressed in liver [15]. It has been reported that the intracellular localization of 17␤HSD13 is similar to that of HCV core protein in endoplasmic reticulum (ER), lipid droplets (LDs), and mitochondria [16][17][18], while it is unknown whether 17␤HSD13 localizes in mitochondria or not.…”

Section: Functions Of the Fluctuating Liver Mitochondrial Proteins Rementioning

confidence: 99%

Liquid chromatographic separation of proteins derivatized with a fluorogenic reagent at cysteinyl residues on a non-porous column for differential proteomics analysis

Koshiyama

Ichibangase

Moriya

et al. 2011

Journal of Chromatography A

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Section: Functions Of the Fluctuating Liver Mitochondrial Proteins Rementioning

confidence: 99%

Liquid chromatographic separation of proteins derivatized with a fluorogenic reagent at cysteinyl residues on a non-porous column for differential proteomics analysis

Koshiyama

Ichibangase

Moriya

et al. 2011

Journal of Chromatography A

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“…HSD17B13 which is known as short-chain dehydrogenase/reductase 9 is a lipid dropletassociated protein [44]; and its down expression has been proven in human liver [45]. HK2 is a major isozyme that is involved in glycolysis, which played a key role in promoting anabolic pathways, and is frequently over-expressed in different cancers [56].…”

Section: The Differentially Expressed Proteins In the Primary Hcc Witmentioning

confidence: 99%

Comparative analysis of primary hepatocellular carcinoma with single and multiple lesions by iTRAQ-based quantitative proteomics

Xing

Huang

Wang

et al. 2015

Journal of Proteomics

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“…After characterization of the dual-localization signal sequence of 17b-HSD11, 15) 17b-hydroxysteroid dehydrogenase type 13 (17b-HSD13) was suggested as a LD-associated protein by its homologous N-terminal sequence. 16) Biochemical analysis confirmed that 17b-HSD13 is a liver-specific LD-associated protein. However, its tissue distributions is overlapped but distinct, and the modes of regulated expression are profoundly different.…”

Section: B-hydroxysteroid Dehydrogenase Type 11 and 13 Are Liver-enmentioning

confidence: 80%

“…These results suggest that 17b-HSD11 and 17b-HSD13 have distinct physiologic roles. 16) 17b-HSD11 and 17b-HSD13 are liver-enriched LD-associated accessory proteins that are not essential components of LDs. Notably, our pulse-chase experiment suggested that 17b-HSD11 is redistributed to preexisting LDs via the ER.…”

Section: B-hydroxysteroid Dehydrogenase Type 11 and 13 Are Liver-enmentioning

confidence: 99%

Physiologic Roles of Hepatic Lipid Droplets and Involvement of Peroxisome Proliferator-Activated Receptor .ALPHA. in Their Dynamism

Aishan

Horiguchi

Motojima

2010

Biological & Pharmaceutical Bulletin

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The liver is not a storage site of excess energy as triacylglycerides but a major site of carbohydrate storage, playing a vital role in glucose homeostasis, and the hepatic lipid droplets (LDs) should have a distinct physiologic role from those in lipid-storing tissues. Most studies so far have been limited to characterization of the LDs in cultured cells or of the liver of animals maintained on a normal laboratory diet, and little is known about the properties of the LDs in the liver responding to dietary excess, irregular fats, and potentially toxic compounds contained in a natural food diet. We started to characterize the hepatic LDs in wild-type and peroxisome proliferator-activated receptor a a (PPARa a)-null mice fed various natural diets by identifying the liver-enriched LDassociated proteins and the changes in lipid compositions. Based on the currently available data, we propose the hypothesis that hepatic LDs play vital protective roles against diet-derived excess fatty acids and potentially toxic hydrophobic compounds by temporarily storing them as neutral lipids or compounds until completion of the remodeling of fatty acids and detoxification of the compounds in a PPARa a-dependent manner.

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17β-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein

Cited by 70 publications

References 18 publications

Liquid chromatographic separation of proteins derivatized with a fluorogenic reagent at cysteinyl residues on a non-porous column for differential proteomics analysis

Liquid chromatographic separation of proteins derivatized with a fluorogenic reagent at cysteinyl residues on a non-porous column for differential proteomics analysis

Comparative analysis of primary hepatocellular carcinoma with single and multiple lesions by iTRAQ-based quantitative proteomics

Physiologic Roles of Hepatic Lipid Droplets and Involvement of Peroxisome Proliferator-Activated Receptor .ALPHA. in Their Dynamism

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