17β-Estradiol-dependent regulation of chaperone expression and telomerase activity in the marine sponge Geodia cydonium

Wiens, Matthias; Seack, Jürgen; Koziol, Claudia; Hassanein, Hamdy; Steffen, Renate; Korzhev, Michael; Schröder, Heinz C.; Müller, Werner

doi:10.1007/s002270050436

Cited by 12 publications

(7 citation statements)

References 37 publications

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“…Estrogen action in invertebrates is not understood, and diverse effects of exogenous estrogens on invertebrates have been reported, including stimulated ovarian and/or oocyte development (Shoenmakers et al 1981, Sarojini et al 1986, Wasson et al 2000, blocked embryonic development (Hathaway & Black 1969), altered enzymatic activities (Ghosh & Ray 1993a,b), accumulation of proteins (Ghosh & Ray 1992, Wiens et al 1999, Billinghurst et al 2000, and cellular damage or even apoptosis (Wiens et al 1999, Viarengo et al 2000. On the other hand, some studies have failed to detect effects of exogenous estrogens on invertebrates (Hutchinson et al 1999, Breitholtz & Bengtsson 2001, Pascoe et al 2002.…”

Section: Introductionmentioning

confidence: 99%

Effects of steroidal estrogens on coral growth and reproduction

Tarrant¹,

Atkinson²,

Atkinson³

2004

Mar. Ecol. Prog. Ser.

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Steroidal estrogens are well-described vertebrate hormones that also occur in invertebrates, where they have diverse biological effects. Estradiol-17β is contained in coral tissues and released into the surrounding water during multi-species coral mass-spawning events. Estrogens are also widely distributed environmental pollutants in coastal waters; thus corals and other reef invertebrates are exposed to a variety of estrogens and estrogen-like compounds with unknown organismal and ecological effects. Until now, there has been no experimental evidence to suggest that estrogens are biologically active in corals. We describe the effects of exogenous estradiol on the size and number of gametes spawned by coral colonies and the effects of estrone on coral growth rates and tissue thickness. Montipora capitata coral colonies treated with estradiol for 3 wk prior to spawning released fewer egg-sperm bundles than controls (29% decrease). Porites compressa coral fragments ('nubbins') exposed continuously to estrone for 2 to 8 wk had lower (13 to 24%) skeletal growth rates than controls. Large coral nubbins that were treated with estrone had thicker tissue. While the mechanism for estrogen action for corals remains unknown, these experiments represent the first account of biological activity of steroidal estrogens in coral.

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Section: Introductionmentioning

confidence: 99%

Effects of steroidal estrogens on coral growth and reproduction

Tarrant¹,

Atkinson²,

Atkinson³

2004

Mar. Ecol. Prog. Ser.

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“…Estrogens in the coastal marine environment possibly affect reproductive biology, through blocked embryonic development (6), altered enzymatic activities (7,8), or cellular damage or apoptosis (10,11). Additional work is needed to describe the distribution and in situ concentrations of these estrogenic compounds, including the relative abundance of various steroidal components.…”

Section: Discussionmentioning

confidence: 99%

“…Scleractinian corals can take up estrogens from the water column at concentrations as low as 300 pg/L (2). Laboratory experiments with sponges, crustaceans, mollusks, and echinoderms have demonstrated that estrogens can have diverse effects, including stimulated ovarian and/or oocyte development (3)(4)(5), blocked embryonic development (6), altered enzymatic activities (7,8), accumulation of proteins (9,10), and cellular damage or apoptosis (10,11). These experiments were conducted using a wide range of experimental conditions, estrogen forms, and concentrations.…”

mentioning

confidence: 99%

Estrogens from sewage in coastal marine environments.

Atkinson

Tarrant

2003

Environ Health Perspect

112

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Estrogens are ancient molecules that act as hormones in vertebrates and are biologically active in diverse animal phyla. Sewage contains natural and synthetic estrogens that are detectable in streams, rivers, and lakes. There are no studies reporting the distribution of steroidal estrogens in marine environments. We measured estrogens in sewage, injection-well water, and coastal tropical and offshore tropical water in the Pacific Ocean, western Atlantic Ocean, and Caribbean Sea. Concentrations of unconjugated estrone ranged from undetectable (< 40 pg/L) in the open ocean to nearly 2,000 pg/L in Key West, Florida, and Rehoboth Bay, Delaware (USA); estrone concentrations were highest near sources of sewage. Enzymatic hydrolysis of steroid conjugates in seawater samples indicated that polar conjugates comprise one-half to two-thirds of "total estrone" (unconjugated plus conjugated) in Hawaiian coastal samples. Adsorption to basalt gravel and carbonate sand was less than 20% per week and indicates that estrogens can easily leach into the marine environment from septic fields and high-estrogen groundwater. Of 20 sites (n = 129 samples), the mean values from 12 sites were above the threshold concentration for uptake into coral, indicating that there is a net uptake of anthropogenic steroidal estrogen into these environments, with unknown impacts.

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“…When estrone concentrations are greater than 300 pg/L, there is the potential of net uptake and potential accumulation in the reef benthos (Atkinson et al, 2003). Estrogens in the coastal marine environment may affect reproductive biology through embryonic development (Hathaway and Black, 1969), altered enzymatic activities (Ghosh and Ray, 1993a;Ghosh and Ray, 1993b) or cellular damage or apoptosis (Wiens et al, 1999;Viarengo et al, 2000). Much more information is required to characterise the presence of human-derived estrogens in marine environments and to determine their potential effects on the marine ecosystem.…”

Section: Introductionmentioning

confidence: 99%

Steroid estrogens in ocean sediments

et al. 2005

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Ocean sediment samples were taken adjacent and 7km from a deep ocean outfall (average depth 80m), the discharge point of an enhanced primary sewage treatment plant. All samples contained steroid estrogens at nanogram per gram levels with higher concentrations at the 7km sampling site. The concentration of estrone ranged from (0.16 -1.17 ng/g), 17β-estradiol (0.22 -2.48 ng/g) and the synthetic 17α-ethinylestradiol (<0.1 -0.5 ng/g). The values detected correspond with estimates based on the proportion of estrogens sorbed to particles in the effluent and the expected proportion of sewage origin particles in the ocean sediments. The results suggest that estrogens associated with the particulate fraction aggregate on contact with high ionic strength seawater and settle to the seafloor after discharge through deep ocean outfalls.

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17β-Estradiol-dependent regulation of chaperone expression and telomerase activity in the marine sponge Geodia cydonium

Cited by 12 publications

References 37 publications

Effects of steroidal estrogens on coral growth and reproduction

Effects of steroidal estrogens on coral growth and reproduction

Estrogens from sewage in coastal marine environments.

Steroid estrogens in ocean sediments

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