17β-Estradiol alleviates intervertebral disc degeneration by inhibiting NF-κB signal pathway

Wang, Haidong; Li, Zhaohui; Huo, Yachong; Tian, Tian; Yang, Dalong; Ma, Lei; Yang, Sidong; Ding, Wenyuan

doi:10.1016/j.lfs.2021.119874

Cited by 18 publications

(15 citation statements)

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“…Although the etiology of IVDD is still unclear, recent studies have found that IVDD is accompanied by a decrease in the number of NPCs and disruption of the ECM balance. Furthermore, apoptosis, inflammation, and senescence of the NPCs can accelerate this process [ 1 – 4 ]. Anti-inflammatory and antioxidant factors have become a research hotspot in the field of IVDD.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous studies have shown that estrogen can inhibit apoptosis of NPCs by activating NF- κ B and PI3K-Akt signaling pathways, which has been confirmed in animal experiments [ 6 – 8 ]. Wang et al evidenced the expression of ER in IVD tissues [ 4 ]. The clinical study by Zhao et al also established that OVX led to a significant decrease in the female estrogen level and promoted the progression of IVDD over a long period of time [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Intervertebral disc (IVD) degeneration (IVDD) is an important cause of lower back pain, but the mechanism of IVDD is still unclear. The cause of IVDD may be related to a decrease in the number of nucleus pulposus cells (NPCs) and disruption of the extracellular matrix (ECM) balance caused by age, inflammation, trauma, genetics, and other factors [ 3 , 4 ]. An earlier preliminary clinical study showed that ovariectomy (OVX) resulted in a significant decrease in the estrogen level of patients; moreover, the Pfirrmann grading of the lumbar IVDs in OVX patients was higher than that in normal patients [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…An earlier preliminary clinical study showed that ovariectomy (OVX) resulted in a significant decrease in the estrogen level of patients; moreover, the Pfirrmann grading of the lumbar IVDs in OVX patients was higher than that in normal patients [ 5 ]. A large number of experiments have evidenced that estrogen can enhance the tolerance of NPCs to inflammation and oxidative stress, reduce cell apoptosis, and improve cell survival rate [ 3 , 4 , 6 – 8 ]. Therefore, the level of estrogen can influence the progression of IVDD.…”

Section: Introductionmentioning

confidence: 99%

“…However, a large number of studies have found that the use of TAM negatively affects the bones, uterus, and other organs [ 9 , 10 ]. Previous investigations have revealed the expression of estrogen receptors in IVD tissues; so far, however, no studies have reported the effect of estrogen receptor modulators (e.g., TAM) on IVDD [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Correlation Analysis between Tamoxifen and Lumbar Intervertebral Disc Degeneration: A Retrospective Case-Control Study

Zhao

Rudd

et al. 2022

Pain Research and Management

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Objectives. To investigate the correlation between tamoxifen (TAM) and lumbar intervertebral disc (IVD) degeneration (IVDD). Methods. The patients who visited the department of spine surgery from January 2015 to December 2020 were retrospectively reviewed. Those with a history of breast cancer surgery were identified and their data were collected. These data included patients' age, body mass index (BMI), menstrual history, postoperative history, drug treatment plan, and imaging data. The participants were divided into the TAM group and the non-TAM group. Lumbar IVDD was assessed by lumbar lordosis (LL), vertebral CT density, lumbar disc height index (DHI), Modic changes, and modified Pfirrmann grading score. SPSS 20 was used for statistical analysis. Results. A total of 75 patients were included in this study, 46 patients in the TAM group and 29 patients in the non-TAM group. No significant differences were present in age, BMI, postoperative history, LL, and vertebral CT density between the two groups. The DHI of L1/2 and L2/3 in the TAM group was lower compared to the non-TAM group ( P = 0.038 and P = 0.034 , respectively), while comparisons regarding the DHI of L3/4, L4/5, and L5/S1, and the average DHI between TAM and non-TAM groups were not significant. The modified Pfirrmann grading scores of the L1/2 and L2/3 IVDs in the TAM group were higher than those in the non-TAM group ( P = 0.004 and P = 0.025 , respectively). Comparisons of L3/4, L4/5, and L5/S1 between the two groups were not significant. The comparisons regarding the occurrence of Modic changes did not show a significant difference between the TAM and non-TAM groups. Conclusions. This study indicates that there might be some positive correlation between TAM use and lumbar IVDD. In particular, the degeneration of L1/2 and L2/3 has shown a correlation with TAM use.

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Section: Discussionmentioning

confidence: 99%