179 Prevalence of silent myocardial infarction in patients with left ventricular systolic dysfunction and associations with dysglycaemia

Abstract

1.6%, p=0.045) (Table 1). Male IgG4-RD patients (n=5) as a group showed a significantly higher average myocardial T1 value relative to the reference group, with 3/5 male patients having an abnormally high myocardial T1 (>2SD above limit of normal). Female IgG4-RD patients (n=6) had similar and normal myocardial T1 values to the reference group (Table 1). Seven of the 11 IgG4-RD patients showed LGE, with 6 of these in a non-ischaemic pattern (Table 1). ECV was not statistically different from reference values (29.5 ± 2.5% vs 27.9 ± 2.5% reference value, p=0.192) (Table 1). Conclusion Patients with IgG4-RD in this cohort demonstrated signs of cardiovascular involvement, including subclinical systolic dysfunction, elevated native T1 times and myocardial fibrosis. Future work in larger cohorts should seek to further define the novel cardiovascular phenotypes of this condition including the effects of systemic immunosuppressive therapy on cardiovascular involvement.