178-P: Cost Effective Streamlined Implementation of the 2009 ASHI Mandated Bone Marrow and Stem Cell Transplantation Confirmatory HLA Typing Standard

Leukemia specific loss of heterozygosity of MHC in a CLL patient: Disease state impacts timing of confirmatory typing

“…Since 2010, verification of HLA typing has been required by the NMDP, but may not be simple to obtain. One proposed algorithm [9] is to draw the verification sample at the evaluation visit, with the second sample drawn separately at least 60 minutes after the primary sample. In the case of the patient described here, this process would not have identified the deleted haplotype because the sample drawn at evaluation consisted primarily of tumor cells.…”