17789 An antioxidant cocktail–containing cosmetic product (Liftactive Cure) prevents air pollution–induced skin hyperpigmentation: Results from the ex vivo Düsseldorf Pollution Skin Test

Krutmann, Jean; Valois, A.; Uthe, I.; Felsner, Ingo; Brenden, Heidi; Kérob, Delphine

doi:10.1016/j.jaad.2020.06.883

Cited by 1 publication

(6 citation statements)

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“…PAHs are highly lipophilic and therefore can easily penetrate through the skin barrier ( Jux et al, 2011 ) and reach the melanocytes, the pigment producing cells resident in the skin. Multiple studies have shown that exposure to other air pollutants such as DEPs is associated with clinical signs of hyperpigmentation ( Krutmann et al, 2020 ; Grether-Beck et al, 2021 ). Last but not least, PCBs are highly persistent environmental pollutants known to have accidentally contaminated rice oil alongside polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls (PCQs) (Yusho accident, Japan, 1968 and Yu-Cheng accident, Taiwan, 1979) ( Masuda, 1985 ).…”

Section: Extrinsic Skin Aging Induced By Environmental Stress Factors...mentioning

confidence: 99%

“… 5 Study can be considered also for the section “Anti-pollution products”. 6 Study can be considered also for the section “PM”, sub-section “DEP” (alongside references Krutmann et al, 2020 ; Grether-Beck et al, 2021 ). 7 Study can be considered also for the section “Tobacco-related fractions”.…”

Section: Intracellular Signaling Pathways Crosstalk: Impacts Of Air P...mentioning

confidence: 99%

“… 6 Study can be considered also for the section “PM”, sub-section “DEP” (alongside references Krutmann et al, 2020 ; Grether-Beck et al, 2021 ). …”

Section: Intracellular Signaling Pathways Crosstalk: Impacts Of Air P...mentioning

confidence: 99%

“…Of these assays, many were biochemical (enzymatic activity, melanin content) ( Suo et al, 2020 ; Shi et al, 2021 ), histological, based on gene and protein expression ( Suo et al, 2020 ; Yang et al, 2020 ; Shi et al, 2021 ; Yang et al, 2022 ), including key markers of various intracellular pathways. Of similar versatility in terms of endpoints and data output were the ex vivo platforms and those based on reconstructed tissue models ( Krutmann et al, 2020 ; Grether-Beck et al, 2021 ). The animal studies usually employed histological endpoints or assessed melanin content, melanocyte density ( Krutmann et al, 2008 ; Abbas et al, 2017 ), while clinical studies were focused primarily on the impact of pollutants on skin color at a macroscopic level ( Vierkötter et al, 2010 ; Peng et al, 2017 ; Nkengne et al, 2021 ) (refer to Section 4.3 ; Subsection 4.3.3.…”

Section: Testing Platforms Used To Study Pigmentation In the Context ...mentioning

confidence: 99%

“…A formulation of the active ingredients applied to an ex vivo human skin model also inhibited genes related to expression of pigmentation. Vitamins C and E formulated with active ingredients (see Table 1 ) applied onto an ex vivo human skin model reduced hyperpigmentation and gene expression of MMP-1 ( Krutmann et al, 2020 ).…”

Section: Testing Platforms Used To Study Pigmentation In the Context ...mentioning

confidence: 99%

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Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution

Bouchard,

Costin

2023

Front. Toxicol.

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Aging is one of the most dynamic biological processes in the human body and is known to carry significant impacts on individuals’ self-esteem. Skin pigmentation is a highly heritable trait made possible by complex, strictly controlled cellular and molecular mechanisms. Genetic, environmental and endocrine factors contribute to the modulation of melanin’s amount, type and distribution in the skin layers. One of the hallmarks of extrinsic skin aging induced by environmental stress factors is the alteration of the constitutive pigmentation pattern clinically defined as senile lentigines and/or melasma or other pigmentary dyschromias. The complexity of pollutants and tobacco smoke as environmental stress factors warrants a thorough understanding of the mechanisms by which they impact skin pigmentation through repeated and long-term exposure. Pre-clinical and clinical studies demonstrated that pollutants are known to induce reactive oxygen species (ROS) or inflammatory events that lead directly or indirectly to skin hyperpigmentation. Another mechanistic direction is provided by Aryl hydrocarbon Receptors (AhR) which were shown to mediate processes leading to skin hyperpigmentation in response to pollutants by regulation of melanogenic enzymes and transcription factors involved in melanin biosynthesis pathway. In this context, we will discuss a diverse range of New Approach Methodologies (NAMs) capable to provide mechanistic insights of the cellular and molecular pathways involved in the action of environmental stress factors on skin pigmentation and to support the design of raw ingredients and formulations intended to counter their impact and of any subsequently needed clinical studies.

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Section: Extrinsic Skin Aging Induced By Environmental Stress Factors...mentioning

confidence: 99%

Section: Intracellular Signaling Pathways Crosstalk: Impacts Of Air P...mentioning

confidence: 99%

“… 6 Study can be considered also for the section “PM”, sub-section “DEP” (alongside references Krutmann et al, 2020 ; Grether-Beck et al, 2021 ). …”

Section: Intracellular Signaling Pathways Crosstalk: Impacts Of Air P...mentioning

confidence: 99%

Section: Testing Platforms Used To Study Pigmentation In the Context ...mentioning

confidence: 99%

Section: Testing Platforms Used To Study Pigmentation In the Context ...mentioning

confidence: 99%

See 3 more Smart Citations

Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution

Bouchard,

Costin

2023

Front. Toxicol.

View full text Add to dashboard Cite

show abstract

17789 An antioxidant cocktail–containing cosmetic product (Liftactive Cure) prevents air pollution–induced skin hyperpigmentation: Results from the ex vivo Düsseldorf Pollution Skin Test

Cited by 1 publication

References 0 publications

Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution

Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution

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