(175) Mechanisms between Sleep and Pain – What Do We Know from Studies of Mediation?

Whibley, Daniel; AlKandari, Nourah; Kristensen, Kaja; Barnish, Max; Rzewuska, Magdalena; Druce, Katie L; Tang, Nicole K. Y.

doi:10.1016/j.jpain.2019.01.095

Cited by 5 publications

(4 citation statements)

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“…Pain can result in depression and sleep disturbances, which have been reported to interact with each other. [40][41][42] Furthermore, in contrast to the findings in patients with depression or pain alone, patients with pain and depression have been reported to experience a greater decrease in physical, mental, and social functioning. [43] In our study, compared with NTM-PD patients without pain, those with pain were significantly more likely to be prescribed anxiolytics/sedatives/ hypnotics, or at least 1 pain or pain-related medication.…”

Section: Discussionmentioning

confidence: 91%

Effects of pain on depression, sleep, exercise tolerance, and quality of life in patients with nontuberculous mycobacterial pulmonary disease

et al. 2021

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The experience and causes of pain in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) have not been clarified. This study aimed to determine the prevalence and severity of bodily pain (BP) in patients with NTM-PD. We also investigated the clinical indicators that contribute to pain. We used a retrospective cross-sectional study design. The participants were 114 NTM-PD patients (109 women) with a mean age of 65 years. The prevalence and severity of pain were measured using 2 items from the 36-Item Short Form Survey version 2 (SF-36), and the BP score was calculated. Functional limitation due to dyspnea was quantified using the Modified Medical Research Council Dyspnea Scale (mMRC), depression was assessed using the Center for Epidemiological Studies Depression Scale (CES-D), sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI); health-related quality of life was assessed using the Leicester Cough Questionnaire (LCQ), and exercise tolerance was measured using the Incremental Shuttle Walk Test (ISWT). Pain was reported by 70.2% of the patients (n = 80), and of these, 35.7% (n = 25) reported moderate to very severe pain. NTM-PD patients with high levels of pain had significantly higher scores on the mMRC, CES-D, and PSQI scores, and significantly lower performance on the ISWT and LCQ. Multiple regression analysis identified ISWT, CES-D, and PSQI as independent factors that affected BP scores. Our findings suggest that pain significantly impacts daily life associated with reduced exercise tolerance, the presence of depressive symptoms, and poor sleep quality in patients with NTM-PD.

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Section: Discussionmentioning

confidence: 91%

Effects of pain on depression, sleep, exercise tolerance, and quality of life in patients with nontuberculous mycobacterial pulmonary disease

et al. 2021

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“…Postoperative fatigue is a common clinical symptom, which often leads to delay in early recovery and affects patients' initiative rehabilitation. [20,21,32] In their meta-analysis of the relationship among pain, sleep, and fatigue, Whibley et al [32] pointed out that these 3 factors influence each other and interact. Only when each factor is positively controlled, this virtuous circle can be established to promote early recovery of patients, shorten the average length of stay in the hospital, and improve patients' satisfaction.…”

Section: Discussionmentioning

confidence: 99%

Application of dexamethasone combined with tranexamic acid in perioperative period of total hip arthroplasty

Huang

Liu

et al. 2022

Medicine

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Objective: To evaluate the efficacy and safety of dexamethasone (DEXA) combined with tranexamic acid (TXA) in the perioperative period of total hip arthroplasty. Materials and Methods: A total of 100 cases were randomly divided into 2 groups (50 cases per group). All patients were given 15 mg/kg TXA before skin incision and 3 hours later. Patients in the intervention group (TXA + DEXA group) were given 20 mg dexamethasone intravenously after the onset of anesthesia, and the same dose of DEXA was administered again 24 hours later. Patients in the placebo group (TXA group) were only given the same dose of normal saline. Postoperative c-reactive protein and interleukin-6, postoperative nausea and vomiting, fatigue visual analogue scale score, postoperative length of stay, range of motion, and consumption of analgesic and antiemetics were statistically analyzed in the 2 groups. Results: The levels of c-reactive protein and interleukin-6 in the TXA + DEXA group were lower than those in the TXA group at 24, 48, 72 hours post-operatively ( P < .001). Walking pain scores in the TXA + DEXA group were also significantly lower than those in the TXA group at 24 and 48 hours ( P < .001); rest pain scores were lower at 24 hours ( P < .001). Compared with the TXA group, the incidence of nausea VAS, postoperative nausea and vomiting, fatigue, analgesia and antiemetics consumption, postoperative length of stay, and range of motion were lower in the TXA + DEXA group (all P < .05), while there were no significant differences in postoperative hematocrit, total blood loss, and complications ( P > .05). Conclusion: The combination of TXA (15 mg/kg; before skin incision and 3 hours later) and DEX (20 mg dexamethasone intravenously after the onset of anesthesia, and again 24 hours later) is an effective and safe strategy for patients undergoing total hip arthroplasty.

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“…22 Some studies suggest that sleep deprivation causes the release of in ammatory factors that affect the regulation of the hypothalamic-pituitary-adrenal axis, reducing the secretion of dopamine and thus causing musculoskeletal pain; 23 others assume that sleep deprivation causes increased sensitivity to pain sensation, decreased willingness to exercise and a range of psychological problems such as anxiety, depression and fear of pain, which are mutually reinforcing with musculoskeletal pain. 24,25 This study did not further analyze the risk factors for musculoskeletal pain in each part of the body, and expanding the sample size to study their risk factors in different parts of the body would be more effective in preventing musculoskeletal pain.…”

Section: Basic Characteristics Of Survey Respondentsmentioning

confidence: 99%

Lack of regular physical activity and adequate sleep are risk factors for musculoskeletal pain in medical college students - a cross-sectional study

Zheng

Rong

Meng

et al. 2023

Preprint

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Background During January-May 2020, novel coronavirus outbreak occurred in East China, and many medical college students, implemented a home protection policy, resulting in significant changes in their physical activity and lifestyle habits. This work aims to analyze the effects of usual physical activity habits, changes in physical activity and lifestyle habits during home protection on the occurrence of musculoskeletal pain from multiple perspectives, and to provide new clues for the search of risk factors for musculoskeletal pain and alternative solutions for the prevention. Methods A cross-sectional study was conducted using questionnaires from 900 randomly selected medical students who had taken home protection between January and May 2020 from four medical universities in East China. Participants completed surveys on socio-demographic characteristics, days of home protection, physical activity in daily life, changes in physical activity during home protection, and daily routine, and reported the location of musculoskeletal pain during home protection. Pain was assessed using Visual Analogue Scale (VAS) scores, and considered to be present if the VAS score > 0. The questionnaire data were double-checked and entered into Epi Data 3.0 to create a database, and SPSS 19.0 was used for statistical analysis. The correlation between measures and musculoskeletal pain was determined using the Mann-Whitney U test, and the correlation between categorical variables and musculoskeletal pain was determined using the chi-square test, and multi-factor logistic regression analysis was used to remove confounding factors and screen for risk factors. The test level was set at α = 0.05. Results The prevalence of musculoskeletal pain during home protection was 40.2% (n = 345; 95% CI 36.9%-43.4%). Multi-factor logistic regression analysis revealed that the females (OR 1.391; 95% CI 1.006–1.922), irregular physical activity in daily life (OR 1.648; 95% CI 1.157–2.347), and less than 6 hours of sleep per day during home protection (OR 1.474; 95% CI 1.020–2.131) were found to be risk factors for musculoskeletal pain. Conclusions Female medical students should pay more attention to the prevention of musculoskeletal pain; regular physical activity in daily life and sufficient sleep time may prevent the occurrence of musculoskeletal pain.

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(175) Mechanisms between Sleep and Pain – What Do We Know from Studies of Mediation?

Cited by 5 publications

References 0 publications

Effects of pain on depression, sleep, exercise tolerance, and quality of life in patients with nontuberculous mycobacterial pulmonary disease

Effects of pain on depression, sleep, exercise tolerance, and quality of life in patients with nontuberculous mycobacterial pulmonary disease

Application of dexamethasone combined with tranexamic acid in perioperative period of total hip arthroplasty

Lack of regular physical activity and adequate sleep are risk factors for musculoskeletal pain in medical college students - a cross-sectional study

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