1995
DOI: 10.1097/00024382-199505000-00176
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175 Detection of Anastomotic Leaks After Colorectal Surgery by Measuring LPS in the Drainage Fluid

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Cited by 14 publications
(20 citation statements)
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“…There is evidence of local ischaemia 24 h after surgery in patients who subsequently develop AL , while rises in lactate and lactate/pyruvate levels precede clinical detection of AL by several days . Similarly, systemic and peritoneal inflammatory mediators rise significantly by POD 2 (in some cases, within hours) in patients who subsequently develop AL . Thus, our findings suggesting that AL is an early event are supported by biochemical evidence in the extant literature.…”
Section: Discussionsupporting
confidence: 82%
“…There is evidence of local ischaemia 24 h after surgery in patients who subsequently develop AL , while rises in lactate and lactate/pyruvate levels precede clinical detection of AL by several days . Similarly, systemic and peritoneal inflammatory mediators rise significantly by POD 2 (in some cases, within hours) in patients who subsequently develop AL . Thus, our findings suggesting that AL is an early event are supported by biochemical evidence in the extant literature.…”
Section: Discussionsupporting
confidence: 82%
“…A few investigational studies have focused on biochemical analysis of effluents of abdominal drains in patients who underwent colorectal anastomosis. Positive correlations with anastomotic leakage were found for lysozyme activity level and endotoxins [20,21] . The value of these findings in daily clinical practice, however, is probably limited.…”
Section: Discussionmentioning
confidence: 87%
“…By measuring sensitive markers of coagulation activation and fibrinolysis, anastomotic leakage may be predicted. Endotoxin concentration in drainage fluid has also been found to be a valuable parameter for the detection of anastomotic leak 30 …”
Section: Discussionmentioning
confidence: 99%