-174G>C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease

Abstract

BACKGROUND AND OBJECTIVES:A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians.PATIENTS AND METHODS:Study subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR–restriction fragment length polymorphism.RESULTSThe frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity).CONCLUSIONThe -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians.

Associations of urinary sodium and sodium to potassium ratio with hypertension prevalence and the risk of cardiovascular events in patients with prehypertension

“…Their results demonstrated that a reduction in salt intake was accompanied by reduced production of the proinflammatory cytokines IL‐6 and IL‐23 . In addition, increased levels of inflammatory cytokines are reported in hypertension, and IL‐6 and TNF‐α are associated with BP variability and CAD . These studies demonstrate that IL‐6 is associated with high‐salt diets, hypertension, and CAD, but these associations were not reflected by the Na‐K ratio and the effects of a long‐term high‐salt diet on inflammatory factors in the population with prehypertension.…”

Association of inflammatory genes with neuroticism, anxiety and depression in male patients with coronary heart disease

“…Однако это предположение не подтверждается данными литературы. Так, в ряде исследований [24,25] не было обнаружено ассоциации между IL-6 C-174G и ишемической болезнью сердца, а в публикациях [26][27][28] сообщалось об ассоциации, однако вариантом риска являлся генотип СС. Другое возможное объяснение отмеченной тенденции заключается в том, что разделение больных по признаку наличия депрессии неизбежно носит субъективный характер, и в группу без депрессии могли попасть пациенты, у которых симптомы могли проявиться позже.…”

Pleiotropic Effects of White Willow Bark and 1,2-Decanediol on Human Adult Keratinocytes

“…IL-6 is a pleiotropic cytokine that plays a pivotal role in host defense, immune response regulation, hematopoiesis, and inflammation [32]. Single-nucleotide polymorphisms in the IL-6 gene have been identified and associated with several diseases [33,34]. However, there are relatively few studies on IL-6 gene polymorphism in acne patients.…”