Abstract:Background and aimExtensive studies have revealed an important protective function for IgM antibodies from B1a cells in atherosclerosis, whereas the role of B2 cells and IgG antibodies is uncertain, with both pro- and anti-atherogenic actions reported. The aim of this study was to specifically target antibodies but not other B cell functions and determine the effect on mouse atherosclerosis.MethodsWe created MB1-Cre x XBP1fl/fl mice that have B cell specific deficiency in the unfolded protein response transcri… Show more
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