1734 High Density Lipoprotein (Hdl) Serum Levels Are Correlated to Histologic Features of Inflammatory Infiltrate and Weight of Prostatic Adenoma in Men Treated With Simple Prostatectomy for Benign Prostatic Hyperplasia

Gacci, Mauro; Santi, Raffaella; Nesi, Gabriella; Giannessi, Claudia; Sebastianelli, Arcangelo; Giancane, S.; Khorrami, Saba; Salvi, Matteo; Vignozzi, Linda; Morelli, Annamaria; Corona, Giovanni; Serni, Sergio; Carini, Marco; Maggi, Mario

doi:10.1016/j.juro.2012.02.1695

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“…Furthermore, after prostatectomy, prostate specimen weight was negatively correlated with HDL levels. Receiver operating characteristic (ROC) curves showed that inflammatory infiltrate grade, extent, and the presence of glandular disruption predicted reduced HDL-cholesterol with an accuracy of 67.4%, 72.4%, and 70.2%, respectively [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Endogenous Sphingolipid Signaling Pathway Implicated in the Action of Croton membranaceus on the Prostate Gland in BPH Patients

et al. 2017

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Background: Croton membranaceus extract has apoptotic effects on BPH-1 cells. This study determined if the apoptotic effects were created through the ceramide pathway. Methods: The study was a follow-up to a previous observational study of 30 histologically confirmed patients with benign prostatic hyperplasia (BPH) who were on C. membranaceus ethanolic extract at 20 mg t.i.d orally for 3 mo. Thereafter, total and free prostate-specific antigen (PSA), lipid profile plus Apo lipoprotein A and B, ceramide/Sphingophospho-kinase 1 (SphK1) and 2 (SphK2), sphingosine lyase (SPL), the cytotoxic adducts of oxidative stress 4-hydroxy-2-nonenal (4HNE) and malondialdehyde (MDA), were determined. Results: Total and free PSA were significantly (p < 0.05) different after treatment. Apo lipoprotein A was significantly different (p = 0.024). The SphK1/SphK2 ratio reduced significantly (p = 0.049). Furthermore, SPL, ceramide, and MDA increased significantly after treatment (p = 0.05, p = 0.004, and p = 0.007, respectively). A weak positive correlation was found between high-density lipoprotein (HDL) cholesterol and SphK1, and HDL and ceramide before treatment (p = 0.036, r = 0.3826; p = 0.018, r = 0.4286, respectively. Conclusions: C. membranaceus uses the ceramide pathway by modulating the SphK1/SphK2 ratio and increasing SPL to generate oxidative stress and consequently apoptosis.

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Section: Discussionmentioning

confidence: 99%