1719P Predictive value of DNA repair gene alterations for the response to platinum-based chemotherapy and immunotherapy in advanced solid tumors patients: Results from a single center molecular screening program

Chabot, C.; Cousin, Sophie; Khalifa, Emmanuel; Ceruso, Mariella Spalato; Soubeyran, Isabelle; Laizet, Yec’han; Crombé, Amandine; Italiano, A.

doi:10.1016/j.annonc.2022.07.1797

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“…DNA repair system was an important cellular adaption and response system to recover the DNA replication errors that were caused by different types of external stimuli and damages for instance environmental toxins, UV light, radiation therapy, chemotherapy and so on [46,47]. The main methods for DNA repair system composed of base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MRR), homologous recombination repair (HRR) and non homologous end joining (NHEJ) [48,49].…”

Section: Discussionmentioning

confidence: 99%

ARHGAP44 gene: a cytoskeleton mobility related modulator with potential implication in pan-cancer prognosis risk prediction and immune regulation

Shen,

Yang,

Wang

et al. 2024

Preprint

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Background Rho GTPases has been a well known family of small G proteins that regulate cellular cytoskeleton dynamics and involve in multiple critical steps of cancer progression. However, ARHGAP44 gene which is a member of GAP proteins that regulates the Rho GTPases cycling between their active GTP-bound and inactive GDP-bound state, its role in cancer development is still lack of understanding. The study is to analyze the function of ARHGAP44 gene in broad spectrum human cancers, thus aiding better understanding of the collaborative network of cytoskeleton related genes in cancers. Methods In the study, we started with the analysis of the genetic characteristics of ARHGAP44 gene, followed by its expression patterns, frequent alterations as well as survival prediction value in broad spectrum human cancers. Further, the probable reasons for the aberrant changed expression of ARHGAP44 in cancers comparing to corresponding normal control samples were investigated. Moreover, the correlation of ARHGAP44 with multiple critical clinical cancer parameters were in succession performed. Results Firstly, basic genetic physicochemical properties of ARHGAP44 including its aminoacid composition, estimated molecular weight and protein half life were investigated. Then, genetic alteration analysis revealed that ARHGAP44 expression various in human cancers, which was partly due to the modulation by DNA methylation and phosphorylation. Further, ARHGAP44 gene was indicated to be associated with multiple critical cancer traits including cancer stemness, cytoskeleton dynamics as well as immune infiltration in different human cancer types. Moreover, ARHGAP44 gene was also supported to be associated with the sensitivity of several chemotherapy related drugs. Conclusions Based on multiple analysis, some valuable strategies to guide the therapeutic orientation concerning the role of ARHGAP44 gene in human cancers were revealed, although more detailed experiments and clinical trials are obligatory to support further clinical medical application of the gene, especially in each independent type of cancers.

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Section: Discussionmentioning

confidence: 99%