167-A,a new antibiotic produced by a mutant of an inactive wild strain of Amycolata autotrophica.

Malkina, N. D.; Dudnik, Yuri V.; Lysenkova, Lyudmila N.; Lazhko, E. I.; Galatenko, O. A.; Katrukha, Guenrich S.

doi:10.7164/antibiotics.47.342

Cited by 11 publications

(2 citation statements)

References 9 publications

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“…71 Quinones from natural sources have a variety of biological activities, and are particularly well-known for their bactericidal properties. 72,73 3,4-Dihydroxy-1-methoxyanthraquinone-2-carboxaldehyde (93) and damnacanthal (94), were identified from the aerial part of Saprosma fragrans as antifungal compounds with MIC values as follows: 93: 12.5 mg mL À1 (Trichophyton mentagrophytes); 94: 12.5, 6.25 and 1.56 mg mL À1 (Cryptococcus neoformans, Sporothrix schenckii and T. mentagrophytes, respectively). 74 Another anthraquinone containing a naphthaquinone moiety, named newbouldiaquinone A (95), is a constituent of the roots of Newbouldia laevis (Bignoniaceae).…”

Section: Macrolidesmentioning

confidence: 99%

Antimicrobial natural products: an update on future antibioticdrug candidates

et al. 2010

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Over the last decade, it has become clear that antimicrobial drugs are losing their effectiveness due to the evolution of pathogen resistance. There is therefore a continuing need to search for new antibiotics, especially as new drugs only rarely reach the market. Natural products are both fundamental sources of new chemical diversity and integral components of today's pharmaceutical compendium, and the aim of this review is to explore and highlight the diverse natural products that have potential to lead to more effective and less toxic antimicrobial drugs. Although more than 300 natural metabolites with antimicrobial activity have been reported in the period 2000-2008, this review will describe only those with potentially useful antimicrobial activity, viz. with MICs in the range 0.02-10 microg mL(-1). A total of 145 compounds from 13 structural classes are discussed, and over 100 references are cited.

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Section: Macrolidesmentioning

confidence: 99%

Antimicrobial natural products: an update on future antibioticdrug candidates

et al. 2010

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“…The lowest homologue, nonactin (146), is constructed from four nonactic acid subunits (144a), linked in alternating enantiomeric sequence (+ -+ -), so that the overall macrocycle possesses a mesoconfiguration. Monactin (147), dinactin (148), trinactin (149), tetranactin (150), as well as isodinactin (151) and isotrinactin (152), are examples of further macrotetrolide antibiotics.…”

Section: Dinactin; Werramycin-bmentioning

confidence: 99%

Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.

Mahmoud¹

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sources of bioactive constituents, as most medicinal plants (~97%) have been totally investigated. So, many other natural sources were being taken into consideration, especially those located in marine habitats e.g. soft corals, sponges, jellyfishes, algae, and microorganisms. Microorganisms are living symbiotically or located in sediments and represent a huge source of diverse bioactive secondary metabolites. Such diversity increases the possibility of structural novelty as well as bioactivity.Penicillin (1), one of the first antibiotics from microorganisms, was discovered in 1928 by Fleming, showing a bactericidal activity against the Staphylococcus sp.For this great discovery, Fleming, Chian and Florey were honoured with the Nobel Prize in 1945 [7] . Since the discovery of penicillin (1) and mycophenolic acid (2) before [8] , microorganisms, especially bacteria, played an essential role in the production of antibiotics and other drugs for the treatment of current diseases [9, 10] . 7The systematic investigations of marine environment as sources of novel biologically active agents began intensively in the mid 1970s. Among the phyla in the oceans, bacteria, fungi, algae, sponges, coelenterates, sea hares, bryozoans, tunicates and nudibranchs have been studied [28,29] . There is, however, a continual increasing of the reported new compounds from marine sources since 1965 (Figure 1). Sponges followed by coelenterates were the most studied marine organisms. Since that time, 13Didemnin B (13), a depsipeptide, was isolated from the Caribbean tunicateTrididemnum solidum [34] , inhibiting the synthesis of RNA, DNA and proteins in various cancer cell lines. It shows anti-viral and immunosuppressive activities as well as being an effective agent in treatment of leukaemia and melanoma. However, due to its toxicity, it was withdrawn from phase II clinical trials [35,36] .Thiocoraline ( 14), a novel depsipeptide was isolated (1997) from the mycelial extract of the bacterium Micromonospora marina, associated with a marine soft coral in the Indian Ocean. Thiocoraline (14) showed potent cytotoxic activity at a nanomolar concentration against several tumor cell lines. It inhibits DNA polymerase [37,38] . It is currently in preclinical phase by PharmaMar.

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Natural Products as Antimicrobial Agents – an Update

Saleem

2014

Novel Antimicrobial Agents and Strategies

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167-A,a new antibiotic produced by a mutant of an inactive wild strain of Amycolata autotrophica.

Cited by 11 publications

References 9 publications

Antimicrobial natural products: an update on future antibioticdrug candidates

Antimicrobial natural products: an update on future antibioticdrug candidates

Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.

Natural Products as Antimicrobial Agents – an Update

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