Highlights
Large cell neuroendocrine carcinoma of the colon is rare and aggressive, and its prognosis is very poor.
Effective treatment of large cell neuroendocrine carcinoma of the colon has not been established.
If local Large cell neuroendocrine carcinoma is completely resected, the 5-year survival rate has been reported to be 61%.
Most patients are metastatic and not candidates for curative resection.
The efficacy of systemic chemotherapy is highest in patients with poorly differentiated neuroendocrine tumors with a combination of cisplatin and etoposide.