161p Soluble Mesothelin Related Protein (Smrp) in Malignant Pleural Mesothelioma (Mpm)

Azim, Hamdy A.; Gaafar, Rabab; Abdelsalam, Ibrahim M.; Khorshid, Ola; Elguindi, Sharif; Elattar, Inas; Ashmawy, Ahmed M

doi:10.1016/s0169-5002(09)70284-3

Cited by 5 publications

(10 citation statements)

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“…SMRP/mesothelin in serum is a noninvasive marker that can be helpful in making the diagnosis of mesothelioma, as the assay in the pivotal study had a sensitivity of 84% for mesothelioma, and 100% specificity in differentiating mesothelioma from other pleural diseases, 95% against other lung cancers and 100% against apparently healthy subjects [16]. However, in another study, the best combination of sensitivity and specificity against controls was 66% and 70.9%, respectively [125]. Moreover, as evaluation of response and recurrence by imaging techniques is difficult in mesothelioma, SMRP level is a sensitive measure of tumour burden as it is increased in more advanced disease [125].…”

Section: Biomarkersmentioning

confidence: 95%

Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

2015

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Asbestos is the term for a family of naturally occurring minerals that have been used on a small scale since ancient times. Industrialisation demanded increased mining and refining in the 20th century, and in 1960, Wagner, Sleggs and Marchand from South Africa linked asbestos to mesothelioma, paving the way to the current knowledge of the aetiology, epidemiology and biology of malignant pleural mesothelioma. Pleural mesothelioma is one of the most lethal cancers, with increasing incidence worldwide. This review will give some snapshots of the history of pleural mesothelioma discovery, and the body of epidemiological and biological research, including some of the controversies and unresolved questions. Translational research is currently unravelling novel circulating biomarkers for earlier diagnosis and novel treatment targets. Current breakthrough discoveries of clinically promising noninvasive biomarkers, such as the 13-protein signature, microRNAs and the BAP1 mesothelioma/cancer syndrome, are highlighted. The asbestos history is a lesson to not be repeated, but here we also review recent in vivo and in vitro studies showing that manmade carbon nanofibres could pose a similar danger to human health. This should be taken seriously by regulatory bodies to ensure thorough testing of novel materials before release in the society. @ERSpublications Malignant pleural mesothelioma is a cancer with increasing death tolls due to the past and present use of asbestos http://ow.ly/DhA2y

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Section: Biomarkersmentioning

confidence: 95%

Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

2015

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“…Furthermore, it has been demonstrated that its levels in patients with MM are significantly higher when compared with those of patients with other cancers (including lung cancer) or other inflammatory lung or pleural diseases [16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: Diagnostic Performancementioning

confidence: 99%

“…However, four studies showed that patients with advancedstage MM had significantly higher concentrations compared to those with stage I disease [19,21,22,27].…”

Section: Diagnostic Performancementioning

confidence: 99%

“…Several studies have proposed that mesothelin values are positively associated with age and inversely associated with weight, BMI, performance status, blood glucose, % predicted single-breath carbon monoxide diffusing capacity and singlebreath carbon monoxide diffusing capacity per unit alveolar volume [27,40,64]. Moreover, although there is no clear explanation, a correlation between elevated mesothelin and high serum alkaline phosphatase has been observed [27].…”

Section: Effect Of Patient Characteristics On Mesothelin Mpf and Ostmentioning

confidence: 99%

“…Moreover, although there is no clear explanation, a correlation between elevated mesothelin and high serum alkaline phosphatase has been observed [27].…”

Section: Effect Of Patient Characteristics On Mesothelin Mpf and Ostmentioning

confidence: 99%

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Effectiveness of mesothelin family proteins and osteopontin for malignant mesothelioma: Table 1–

et al. 2012

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Malignant mesothelioma (MM) is an aggressive tumour with poor prognosis whose early diagnosis is difficult. Mesothelin, megakaryocyte potentiating factor (MPF) and osteopontin have attracted attention as biomarkers. The aim of the present review is to provide an overview regarding these candidate biomarkers for MM, and discuss their potential role in today's clinical practice.Mesothelin and MPF have good specificity but sub-optimal sensitivity for detection of MM, being negative both in the sarcomatoid histological sub-type and in almost half of epithelioid mesothelioma, especially in the early stages. Osteopontin is a marker of the duration of asbestos exposure, but lacks specificity for mesothelioma. Several patient characteristics influence the diagnostic accuracy of biomarkers and make the establishment of the ''optimal'' diagnostic threshold difficult. Mesothelin and MPF have proved useful in assessing response to treatment. Combining different markers together may lead to an improvement in diagnostic accuracy, but there is still need for research in this area. Extensive validation and further research is required to improve the use of serum markers in mesothelioma management. In the near future, their application in clinical practice is probably in monitoring response to therapy, rather than in guiding diagnostic decisions and risk assessment of asbestos-exposed populations.

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The established and future biomarkers of malignant pleural mesothelioma

Panou

Vyberg

Weinreich

et al. 2015

Cancer Treatment Reviews

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161p Soluble Mesothelin Related Protein (Smrp) in Malignant Pleural Mesothelioma (Mpm)

Cited by 5 publications

References 0 publications

Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic

Effectiveness of mesothelin family proteins and osteopontin for malignant mesothelioma: Table 1–

The established and future biomarkers of malignant pleural mesothelioma

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