1601 Dutasteride Can Reduce Intraoperative Bleeding During Transurethral Resection of the Prostate: Evaluation of Vascular Endothelial Growth Factor (Vegf) and Cd34

Busetto, Gian Maria; Antonini, Gabriele; Giovannone, Riccardo; Gentile, V.; Berardinis, Ettore De

doi:10.1016/j.juro.2013.02.3151

Cited by 2 publications

(4 citation statements)

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“…This is the first meta-analysis, to our knowledge, to demonstrate that preoperative dutasteride treatment could decrease TURP-related blood loss in BPH patients. When considering the therapy duration, short-term (2-6 weeks) [16,26,27] or moderate-to-long-term (8-24 weeks) [21,23] treatment was superior to that provided to the control group. However, the conclusions were not consistent across studies.…”

Section: Discussionmentioning

confidence: 90%

“…Ten relevant studies [14][15][16][21][22][23][24][25][26][27] were selected for analysis including 1,022 patients in total (521 treated with dutasteride and 501 in the control group). No differences were found in terms of age and the basic physical conditions between the treatment group and control group.…”

Section: Assessment Of Study Qualitymentioning

confidence: 99%

“…Five studies were retrospective cohort studies (LE: 2b) [23][24][25][26][27] , and 5 RCTs (LE: 2a) [14-16, 21, 22] . The methodological quality of these studies was relatively high for one of the RCTs (Jadad scale: 4 of 5 points) [16] and medium for 4 (Jadad scale: 3 of 5 points) [14,15,21,22] . In terms of the 5 non-randomized studies, the quality was relatively high (NOS: 7 of 9 points).…”

Section: Assessment Of Study Qualitymentioning

confidence: 99%

“…One trial [21] was excluded due to the lack of the mean values and SD values. Heterogeneity was detected among the 3 trials; thus, we chose the random-effects model ( I 2 = 76%).…”

Section: Blood Loss Per Gram Of Resected Prostate Tissuementioning

confidence: 99%

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A Systematic Review and Meta-Analysis of the Effects on Dutasteride Treatment for Reducing Surgical Blood Loss during Transurethral Resection of the Prostate

Ren

Lai²,

Jiang³

et al. 2016

Urol Int

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Objective: This systematic review and meta-analysis were performed to evaluate the efficacy of preoperative dutasteride treatment for reducing surgical blood loss in patients undergoing transurethral resection of the prostate (TURP). Methods: A systematic search was performed from the electronic databases including PubMed, EMBASE, and Cochrane Library by May 2016. We followed the search strategy based on Preferred Reporting Items for Systematic Reviews and Meta-analysis statement when examining the literature. Identified articles were strictly appraised for quality and relevance. Results: Five randomized controlled trials (RCTs) and 5 retrospective cohort studies involving 1,022 patients with benign prostate hyperplasia were analyzed based on the inclusion criteria. Pooled analysis revealed that preoperative treatment with dutasteride had a significantly smaller decrease in hemoglobin (weighted mean difference [WMD] -0.47, 95% CI -0.70 to -0.24, p < 0.0001) and hematocrit levels (WMD -1.03, 95% CI -1.73 to -0.33, p = 0.004); However, no signiﬁcant difference has been found in terms of the total blood loss during TURP and blood loos per gram of resected prostatic tissue, the weight of resected prostate tissue, the microvessel density of the prostate, and the transfusion rate between the dutasteride and the control group. Conclusions: This systematic review and meta-analysis indicate that preoperative treatment with dutasteride could reduce surgical bleeding during TURP, but the findings of this study should be further confirmed by well-designed prospective RCTs with a larger patient series.

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Section: Discussionmentioning

confidence: 90%

Section: Assessment Of Study Qualitymentioning

confidence: 99%

Section: Assessment Of Study Qualitymentioning

confidence: 99%

“…One trial [21] was excluded due to the lack of the mean values and SD values. Heterogeneity was detected among the 3 trials; thus, we chose the random-effects model ( I 2 = 76%).…”

Section: Blood Loss Per Gram Of Resected Prostate Tissuementioning

confidence: 99%

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A Systematic Review and Meta-Analysis of the Effects on Dutasteride Treatment for Reducing Surgical Blood Loss during Transurethral Resection of the Prostate

Ren

Lai²,

Jiang³

et al. 2016

Urol Int

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Effect of Preoperative Dutasteride on Bleeding Related to Transurethral Resection of Prostate in Patients with Benign Prostatic Hyperplasia

Rahman¹,

Johura²,

Rasul³

et al. 2019

JBM

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Background: Transurethral resection of prostate (TURP) is the gold standard in the surgical treatment of symptomatic benign prostatic hyperplasia (BPH). Blood loss is one of the most common complications of TURP. Objective: To evaluate the effect of preoperative dutasteride on bleeding related to TURP in patients with BPH. Materials and Methods: This prospective interventional study was done in the department of urology, Dhaka Medical College Hospital, Dhaka, Bangladesh during the period of July 2016 to June 2017. A total of 70 cases of BPH planned for TURP were included in this study according to the statistical calculation. Patients were randomly allocated to control group A (TURP without dutasteride) and dutasteride group B (TURP with dutasteride). Each group consisted of 35 patients. Group B patients were treated with dutasteride 0.5 mg/day for 4 weeks before TURP. The main outcome of blood loss was evaluated in terms of reduction in serum hemoglobin (Hb) and hematocrit (Hct) levels, which were measured before and 24 hours after surgery. Data were analyzed and compared by statistical tests. Results: Comparison of outcome between groups shows that there was a significant difference in term of pre-post operative change of hemoglobin and hematocrit levels in the control group A compared to the dutasteride group B (Hb = 2.96 ± 0.80 gm/dl vs. 1.81 ± 0.71 gm/dl, respectively, p = 0.001; Hct = 11.20% ± 2.12% vs. 6.07% ± 2.02%, respectively, p = 0.02

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1601 Dutasteride Can Reduce Intraoperative Bleeding During Transurethral Resection of the Prostate: Evaluation of Vascular Endothelial Growth Factor (Vegf) and Cd34

Cited by 2 publications

References 0 publications

A Systematic Review and Meta-Analysis of the Effects on Dutasteride Treatment for Reducing Surgical Blood Loss during Transurethral Resection of the Prostate

A Systematic Review and Meta-Analysis of the Effects on Dutasteride Treatment for Reducing Surgical Blood Loss during Transurethral Resection of the Prostate

Effect of Preoperative Dutasteride on Bleeding Related to Transurethral Resection of Prostate in Patients with Benign Prostatic Hyperplasia

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