16-Aryloxyprostaglandins: A new class of potent luteolytic agent

Binder, D.; Bowler, J.; Brown, E. D.; Crossley, N. S.; Hutton, J.; Senior, M.; Slater, Linda; Wilkinson, P; N, Wright

doi:10.1016/s0090-6980(74)80044-4

Cited by 74 publications

(14 citation statements)

References 8 publications

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“…Spears et al (1974), Bose et al (1975), have used analogues of PGF 2a at different doses varying with the compounds. Table 2 presents the results obtained with two 16-aryloxynrostaglandins (Binder et al, 1974). With the first compound, the mean interval from treatment to calving is 29.3 h (± 12.1).…”

Section: Induction Of Calvin~mentioning

confidence: 99%

Use of Prostaglandins for Induction of Parturition in the Cow

Bosc

1979

Calving Problems and Early Viability of the Calf

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Section: Induction Of Calvin~mentioning

confidence: 99%

Use of Prostaglandins for Induction of Parturition in the Cow

Bosc

1979

Calving Problems and Early Viability of the Calf

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“…Cortisone acetate (Cortistab) was obtained from Boots Co. Ltd., and dexamethasone (Opticortenol, 0-5 %) was a gift from Ciba Ltd. I.C.I. 80,996, a synthetic analogue of PGF2oe (Binder, Bowler, Brown, Crossley, Hutton, Senior, Slater, Wilkinson & Wright, 1974;Dukes, Russell & Walpole, 1974) and PGE2 were provided by Dr A. L. Walpole, I.C.I. Ltd., Pharmaceuticals Division, Alderley Park, Cheshire, and prostaglandins E2 and F2oe by Dr J. Pike, Upjohn Co., Kalamazoo, Michigan.…”

Section: Hormone Treatmentsmentioning

confidence: 99%

Parturition in the Guinea-Pig; Plasma Levels of Steroid Hormones, Steroid-Binding Proteins, and Oxytocin, and the Effect of Corticosteroids, Prostaglandins and Adrenocorticotrophin

Illingworth¹,

Challis²,

Ackland³

et al. 1974

Journal of Endocrinology

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Parturition in the guinea-pig is not preceded by any consistent change in the maternal plasma concentrations of progesterone, total unconjugated oestrogens or corticosteroids, or by a significant change in the concentration of progesterone-binding globulin (PBG). The onset of parturition was delayed by high doses of oestrogens (stilboestrol and oestradiol), but was not affected by oestriol or an antiserum raised against oestradiol. Premature parturition was achieved by the intra-carotid infusion of adrenocorticotrophin or prostaglandins (PGF2\g=a\, PGE2, I.C.I. 80,996) in conscious animals with indwelling catheters. I.C.I. 80,996, a potent analogue of PGF2\g=a\, induced parturition in all seven guinea-pigs treated; delivery occurred within 6 h of starting the infusion in six animals, and within 48 h in the seventh. The undesirable side-effects that accompanied treatment with PGF2\g=a\ or PGE2 were not encountered with I.C.I. 80,996. Parturition induced experimentally resembled normal delivery but was not preceded by any significant change in the maternal levels of progesterone, total unconjugated oestrogens, corticosteroids, PBG or CBG in the circulation. Oxytocin was not detected until the delivery of the first foetus.Parturition was not induced by maternal or foetal injections of corticosteroids or dexamethasone. Earlier findings are confirmed that the foetal adrenal grows steadily throughout late pregnancy and, unlike the foetal lamb adrenal, undergoes no rapid phase of growth immediately before term. Foetal adrenal weight decreased relative to foetal body weight.The trigger for parturition in this species remains unidentified.

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“…Racemic ~~S,11R,15R)-9,11,15-trihydroxy-16-(3-trifluoromethylphenoxy)-1 7 , 1 8 , 1 9 , 2 0 -t e t r a n o r -5 -~, 1 acidified with concentrated hydrochloric acid solution, and extracted with ethyl acetate (5 X 10 ml).…”

Section: Introductionmentioning

confidence: 99%

The preparation of [¹⁴C]‐labelled 16‐aryloxy prostaglandin f2α analogues. [I.C.I. 81,008 and I.C.I. 80,996]

White

1977

Labelled Comp Radiopharmac

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The preparations of [14C]‐labelled racemic (95,11R,15R)‐9, 11,15‐trihydroxy‐16‐(3‐trifluoromethylphenoxy)‐17,18,19,20‐tetranor‐5‐cis,13‐trans‐prostadienoic acid [I.C.I. 81,008] from chloro[1‐14C]acetic acid and potassium[14C]cyanide, and [14C]‐labelled racemic (95,11R,15R)‐16‐(3‐chlorophenoxy)‐9,11,15‐trihydroxy‐17,18,19,20‐tetranor‐5‐cis,13‐trans‐prostadienoic acid [I.C.I. 80,996] from chloro[1‐14C]acetic acid and potassium[14C] cyanide are described.

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16-Aryloxyprostaglandins: A new class of potent luteolytic agent

Cited by 74 publications

References 8 publications

Use of Prostaglandins for Induction of Parturition in the Cow

Use of Prostaglandins for Induction of Parturition in the Cow

Parturition in the Guinea-Pig; Plasma Levels of Steroid Hormones, Steroid-Binding Proteins, and Oxytocin, and the Effect of Corticosteroids, Prostaglandins and Adrenocorticotrophin

The preparation of [¹⁴C]‐labelled 16‐aryloxy prostaglandin f2α analogues. [I.C.I. 81,008 and I.C.I. 80,996]

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16-Aryloxyprostaglandins: A new class of potent luteolytic agent

Cited by 74 publications

References 8 publications

Use of Prostaglandins for Induction of Parturition in the Cow

Use of Prostaglandins for Induction of Parturition in the Cow

Parturition in the Guinea-Pig; Plasma Levels of Steroid Hormones, Steroid-Binding Proteins, and Oxytocin, and the Effect of Corticosteroids, Prostaglandins and Adrenocorticotrophin

The preparation of [14C]‐labelled 16‐aryloxy prostaglandin f2α analogues. [I.C.I. 81,008 and I.C.I. 80,996]

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The preparation of [¹⁴C]‐labelled 16‐aryloxy prostaglandin f2α analogues. [I.C.I. 81,008 and I.C.I. 80,996]