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Baumjohann, Dirk; Kageyama, Robin; Clingan, Jonathan M.; Morar, Malika M.; Patel, Sana; Kouchkovsky, Dimitri de; Bannard, Oliver; Bluestone, Jeffrey A.; Matloubian, Mehrdad; Ansel, K. Mark; Jeker, Lukas T.

doi:10.1016/j.cyto.2013.06.019

Cited by 3 publications

(8 citation statements)

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“…It was found that the miR-17-92 cluster's increasing role in regulating the immune system is involved in innate and adaptive immunity, including B cells and subsets of T cells such as Th1, Th2, T follicular helper cells, regulatory T cells, monocytes/macrophages, NK cells, and dendritic cells [46]. Moreover, the study found that the miR-17 approximately 92 cluster is a critical regulator of T cell-dependent antibody responses and follicular helper T cells' (TFH cells) differentiation [47].…”

Section: T Cell Follicular Helper T Cells (Tfh Cells) and Th17mentioning

confidence: 99%

Pathogenic Roles of MicroRNA in the Development of Asthma

Dong¹,

Zhong²

2019

Asthma - Biological Evidences

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Asthma is a common and chronic inflammatory disease. Pathogenic mechanism underlying asthma is complicated. The inflammatory reactions in asthma have been recognized to involve mast cells, eosinophils, lymphocytes (T cells, B cells), macrophages, and dendritic cells. MicroRNA (miRNA, miR) is a group of small noncoding RNAs with 21-25 nucleotides (nt) in length, which impact biologic responses through the regulation of mRNA transcription and/or translation. MicroRNAs are related to developmental processes of many immunologic diseases. Most studies showed that regulation of miRNAs to their targeting genes appears to play an important role in the development of asthma. This chapter has discussed altered expression of miRNAs in cells and tissues from patients with asthma, in order to better understand the mechanics of pathogenesis of asthma. In addition, the regulation of miRNAs as a novel therapeutic approach will require a deeper understanding of their function and mechanism of action.

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Section: T Cell Follicular Helper T Cells (Tfh Cells) and Th17mentioning

confidence: 99%

Pathogenic Roles of MicroRNA in the Development of Asthma

Dong¹,

Zhong²

2019

Asthma - Biological Evidences

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“…Studies of global miRNA depletion in GC B and T cell-specific models showed that miRNAs are essential for proper GC formation (9,10). Dicer-mediated miRNA depletion after AID expression in early activated GC B cells impaired the production of high-affinity class-switched antibodies and the generation of memory B and long-lived plasma cells after T cell-dependent immunization due to defects in B cell proliferation and survival (9).…”

Section: Mirnas In Physiological Gc Regulationmentioning

confidence: 99%

“…Dicer-mediated miRNA depletion after AID expression in early activated GC B cells impaired the production of high-affinity class-switched antibodies and the generation of memory B and long-lived plasma cells after T cell-dependent immunization due to defects in B cell proliferation and survival (9). Likewise, DGCR8-Drosha complex-mediated miRNA depletion in CD4 T cells showed that CD4 T cell-expressed miRNAs are essential for the differentiation of Tfh cells and the induction of GC B cells during T cell-dependent immunizations (10). Interestingly, miRNAs are not only required to regulate Tfh and GC B cell function in a cell intrinsic manner, but are also important contact-independent mediators of T-B cellular communication (Figure 1).…”

Section: Mirnas In Physiological Gc Regulationmentioning

confidence: 99%

“…miR-17-92 cluster expression is induced early in T cell activation (48) and is repressed by BCL6, the critical transcriptional factor that regulates Tfh differentiation (82). T cell-specific miR-17-92 gain-and loss-of function mouse models showed that the microRNAs of the cluster are critical promoters of Tfh and GC B cell differentiation and antigen-specific antibody generation during both T-cell dependent immune responses and chronic viral infection (10,48,49). miR-17-92 cluster miRNAs regulate the ICOS-PI3K signaling pathway in Tfh cells through the simultaneous targeting of different pathway inhibitory components.…”

Section: Mirnas In the Regulation Of Follicular Helper T Cellsmentioning

confidence: 99%

“…miR-17-92 cluster miRNAs regulate the ICOS-PI3K signaling pathway in Tfh cells through the simultaneous targeting of different pathway inhibitory components. miR-17-92 inhibits PTEN phosphatase expression upstream of AKT (10,48,51) as well as the downstream AKT phosphatase PHLPP2 (48). This pathway is additionally regulated in Tfh cells by Roquin, an RNA-binding protein that recognizes specific stem-loop structures in the 3'UTRs of target mRNAs and which interferes with miR-17-92 binding to an overlapping binding site in the Pten mRNA 3'UTR (83).…”

Section: Mirnas In the Regulation Of Follicular Helper T Cellsmentioning

confidence: 99%

See 2 more Smart Citations

microRNA Fine-Tuning of the Germinal Center Response

Fuertes¹,

Salgado²,

Yébenes³

2021

Front. Immunol.

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Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma–antibody-secreting cells and memory B cells. These reactions are tightly controlled by a variety of mechanisms, including the post-transcriptional control of gene expression by microRNAs (miRNAs). Through the development of animal models with B cell-specific modified miRNA expression, we have contributed to the understanding of the role of miRNAs in the regulation of GC responses and in B cell neoplasia. Here, we review recent advances in the understanding of the role of miRNAs in the regulation of B cell and T follicular helper physiology during the GC response and in the diseases associated to GC response dysregulation.

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microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53

Wang

et al. 2015

International Journal of Molecular Medicine

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Abstract. Breast cancer (BC) is the foremost cause of cancerrelated mortality in women worldwide. An increasing number of studies has confirmed that microRNAs (miRNAs or miRs) play an important role in the development and progression of BC. microRNA-214 (miR-214), a member of the miRNA family, has been demonstrated to function as both a tumor suppressor and oncogene in various types of human cancer. However, the biological function of miR-214 in BC remains unclear. The present study was designed to investigate the potential role of miR-214 in the development and progression of BC. Our results revealed that miR-214 expression was significantly increased in the BC tissues compared with the adjacent benign tissues, and that the upregulation of miR-214 was significantly associated with the invasion ability of the BC cells. Furthermore, p53, which has been reported to be downregulated in BC, was predicted to be the target gene of miR-214 using bioinformatics software programs. Moreover, luciferase reporter vectors were constructed and it was confirmed that p53 is a target of miR-214. Following the transfection of miR-214 into BC cells, we found that the overexpression of miR-214 markedly enhanced cell invasion through the downregulation of p53 expression. By contrast, the overexpression of p53 abrogated the effects of miR-214. In conclusion, this study demonstrates that miR-214 functions as an oncogene in BC, at least partly by promoting cell invasion through the downregulation of p53. Therefore, miR-214 may be a potential therapeutic target for the treatment of BC.

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16

Cited by 3 publications

References 0 publications

Pathogenic Roles of MicroRNA in the Development of Asthma

Pathogenic Roles of MicroRNA in the Development of Asthma

microRNA Fine-Tuning of the Germinal Center Response

microRNA-214 enhances the invasion ability of breast cancer cells by targeting p53

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