157 adult-to-adult living donor liver transplantation

Lee, S.G; Park, K.M; Lee, Y.J; Hwang, Shin; Choi, Dae Ki; Ahn, Chul‐Soo; Joo, Sun Hyung; Cheon, Jaekyung; Na, Y.W; Min, Pyung Chul

doi:10.1016/s0041-1345(00)02492-1

Cited by 32 publications

(18 citation statements)

References 4 publications

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“…7,10 We do not believe that the lower graft sur- vival in the LDLT group was secondary to poor recipient risk factors, since those who received LDLT had fewer risk factors compared to our DDLT group. In a series of 157 adult LDLTs performed in Korea from 1997 to 2000, Lee et al 11 reported a sharp decrease in mortality as they gained more experience, 29% in 1997 to 5.7% in 2000. It is possible that such a learning curve, since the data came from many centers in the United States, was one of the factors that determined lower graft survival.…”

Section: Discussionmentioning

confidence: 99%

Graft and patient survival after adult live donor liver transplantation compared to a matched cohort who received a deceased donor transplantation

2004

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Live donor liver transplantation (LDLT) has become increasingly common in the United States and around the world. In this study, we compared the outcome of 764 patients who received LDLT in the United States and compared the results with a matched population that received deceased donor transplantation (DDLT) using the United Network for Organ Sharing (UNOS) database. For each LDLT recipient (n ‫؍‬ 764), two DDLT recipients (n ‫؍‬ 1,470), matched for age, gender, race, diagnosis, and year of transplantation, were selected from the UNOS data after excluding multiple organ transplantation or retransplantation, children, and those with incomplete data. Despite our matching, recipients of LDLT had more stable liver disease, as shown by fewer patients with UNOS status 1 or 2A, in an intensive care unit, or on life support. Creatinine and cold ischemia time were also lower in the LDLT group. Primary graft nonfunction, hyperacute rejection rates, and patient survival by Kaplan-Meier analysis were similar in both groups (2-year survival was 79.0% in LDLT vs. 80.7% in case-controls; P ‫؍‬ .5), but graft survival was significantly lower in LDLT (2-year graft survival was 64.4% vs. 73.3%; P < .001). Cox regression (after adjusting for confounding variables) analysis showed that LDLT recipients were 60% more likely to lose their graft compared to DDLT recipients (hazard ratio [HR] 1.6; confidence interval 1.1-2.5). Among hepatitis C virus (HCV) patients, LDLT recipients showed lower graft survival when compared to those who received DDLT. In conclusion, short-term patient survival in LDLT is similar to that in the DDLT group, but graft survival is significantly lower in LDLT recipients. LDLT is a reasonable option for patients who are unlikely to receive DDLT in a timely fashion. (Liver Transpl 2004; 10:1263-1268.)

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Section: Discussionmentioning

confidence: 99%

Graft and patient survival after adult live donor liver transplantation compared to a matched cohort who received a deceased donor transplantation

2004

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“…MRI is often used in the evaluation of living donors because it offers accurate evaluation of liver volume and of biliary and vascular anatomy as well as a qualitative assessment of hepatic steatosis. [12][13][14] Furthermore, MRI has been well described as a technique for qualitative assessment of hepatic steatosis. [15][16][17][18] In this study, we examined the ability of dual-echo, chemical shift gradient-echo MRI to predict the degree of steatosis on liver biopsy.…”

mentioning

confidence: 99%

Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donation

Rinella

McCarthy

Thakrar

et al. 2003

Liver Transplantation

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In living liver donation, a fatty liver poses risks for both recipient and donor. Currently, liver biopsy is the standard for assessing the presence and extent of steatosis. The goals of this study were to correlate a steatosis index derived from magnetic resonance imaging (MRI) to the histologic grade on biopsy as well as to determine the topographic distribution of steatosis within the liver. We examined the ability of dual-echo, chemical shift gradientecho MRI to predict the degree of steatosis on liver biopsy. A total of 22 subjects received both a liver biopsy and detailed MRI evaluation. These individuals included 15 potential living donors and 7 patients with nonalcoholic fatty liver disease. MRI steatosis index was then compared with histologic grade on liver biopsy. The topographic distribution of hepatic steatosis was determined from those subjects in whom MRI detected hepatic steatosis.

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“…The reported 1-year survival rate is 70%-80%. [29][30][31][32][33][34][35][36][37][38][39][40][41] Therefore, the benefi t of this treatment for any given patient must be clear so that transplantation can be used with maximum effect.…”

Section: Comparison Of Survival Between Patients With Cirrhosis and Tmentioning

confidence: 99%

“…Thus, the number of living donor liver transplantations (LDLT) is gradually increasing, as many patients and their families cannot wait for a cadaveric donor because their condition is life-threatening. [21][22][23][24][25][26][27][28] Although liver transplantation is an effective treatment for patients with liver cirrhosis, there are some defi nite risks, [29][30][31][32][33][34][35][36][37][38][39][40][41] and some patients die prematurely owing to complications of liver transplantation. Thus, it is the important to be able to predict precisely the natural course of liver cirrhosis and to compare the risks and benefi ts of liver transplantation with those of the natural disease course.…”

Section: Introductionmentioning

confidence: 99%

Use of the Model for End-Stage Liver Disease (MELD) score to predict 1-year survival of Japanese patients with cirrhosis and to determine who will benefit from living donor liver transplantation

et al. 2008

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157 adult-to-adult living donor liver transplantation

Cited by 32 publications

References 4 publications

Graft and patient survival after adult live donor liver transplantation compared to a matched cohort who received a deceased donor transplantation

Graft and patient survival after adult live donor liver transplantation compared to a matched cohort who received a deceased donor transplantation

Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donation

Use of the Model for End-Stage Liver Disease (MELD) score to predict 1-year survival of Japanese patients with cirrhosis and to determine who will benefit from living donor liver transplantation

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