1558: Reduction of Venous Thromboembolism in Trauma Patients With Targeted Enoxaparin Dose Adjustment

Abstract

INTRODUCTION/HYPOTHESIS:The current standard venous thromboembolism (VTE) chemoprophylaxis dose for trauma patients is inadequate at providing sufficient protection against the formation of deep vein thrombosis and pulmonary embolism. Anti-factor Xa-guided enoxaparin dosing has successfully decreased the occurrence of VTE in trauma patients at several institutions. The purpose of this systematic review is to present the current literature on anti-factor Xa-guided enoxaparin dosing approaches for VTE chemoprophylaxis and also to present the association between anti-factor Xa levels with the occurrence of VTE in a concise and organized manner. METHODS:Four electronic databases, PubMed, EMBASE, JAMA network, and CINAHL Complete, were searched for articles regarding anti-factor Xa-guided enoxaparin dosing approaches and VTE chemoprophylaxis in the trauma patient population. The study was conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The quality of evidence was assessed using the GRADE Working Group criteria.