151. Synthetic antimalarials. Part XIV. Some 2-arylamino-4-aminoalkylaminoquinazolines

Curd, F. H. S.; Landquist, J. K.; Rose, F. L.

doi:10.1039/jr9470000775

Cited by 31 publications

(11 citation statements)

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“…10 Robert Haworth and Stanley Robinson synthesized and tested quinazoline analog compounds discussed by Curd et al (Figure 1). 11,12 Their research basically involved the preparation of 1,4-dichlorophthalazine and 2,3dichloroquinoxaline. In addition, amino groups, substituted anilines or dialkylamino groups successively replaced the halogen groups.…”

Section: Quinoxaline Derivativesmentioning

confidence: 99%

Quinoxaline and Arylaminoalcohol Derivatives as Antiplasmodial and Leishmanicidal Agents: A Review of our First Ten Years in the Field

Quiliano¹,

Aldana²

2013

Revista Virtual De Química

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Resumo: Doenças negligenciadas constituem um grande problema de saúde na atualidade. Contudo, estas doenças não são de interesse para a indústria farmacêutica, uma vez que elas geralmente afetam pessoas de baixo poder aquisitivo. Descrevemos aqui, o trabalho relacionado à malária e à leishmaniose que estamos desenvolvendo ao longo da última década. Nossa experiência neste campo é focada em duas famílias de compostos químicos: derivados de quinoxalina e aril -amino-álcool. Atualmente, esforços estão centralizados na pesquisa de novas entidades químicas, bem como na superação da resistência a compostos antimaláricos. Adicionalmente, entidades químicas relatadas por outros autores e derivados de quinoxalina relacionados são a bordadas. Estas duas doenças são consideradas de extremo interesse científico e social, necessitando tanto de novos fármacos quanto do aperfeiçoamento dos tratamentos existentes. Palavras-chave:Malária; Leishmaniose; Quinoxalina di-N-óxido; Aril-amino-álcool. AbstractsNeglected diseases constitute a great health problem in today's world. However, these diseases are not of interest to the pharmaceutical industry as they generally affect populations of scarce economical resources. Here, we describe the work related to mal aria and leishmaniasis that we have developed over the last ten years. Our experience in the field is focused on two families of chemical compounds: quinoxaline and arylamino alcohol derivatives. Current efforts are centered on researching new chemical entities as well as on overcoming drug resistance to antimalarial compounds. In addition, chemical entities reported by other authors and related quinoxaline derivatives are addressed. These two diseases are considered to be of great scientific and social interest, requiring new drugs so as to achieve improved treatments.

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Section: Quinoxaline Derivativesmentioning

confidence: 99%

Quinoxaline and Arylaminoalcohol Derivatives as Antiplasmodial and Leishmanicidal Agents: A Review of our First Ten Years in the Field

Quiliano¹,

Aldana²

2013

Revista Virtual De Química

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“…The following starting compounds were prepared according to the previously described methods: piperidin-4-ylthiol [1] , 1-methylpiperidin-4-ylthiol [1,6] , 1-(3-chloropropyl)-4-phenylpiperazine [7] , 1-benzyl-4-(3-chloropropyl)piperazine [8] , 1-(4-chlorobenzyl)-4-(3-chloropropyl)piperazine [9] , 2-chloroquinoline [10] , 1-chloroisoquinoline [11] , 3-chloroisoquinoline [12] , 1,3-dichloroisoquinoline [12,13] , 1-chloro-3-methoxyisoquinoline [12] , 4-chloroquinazoline [14] , 2,4-dichloroquinazoline [15] , and 4-chlorophthalazine [16] .…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and Analgesic Activity of Some Condensed Analogs of Anpirtoline

Rádl

Kovářová

Hezky

et al. 1999

Arch. Pharm. Pharm. Med. Chem.

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New condensed derivatives of anpirtoline, in which the pyridine ring is replaced with quinoline, isoquinoline, quinazoline, and phthalazine nuclei, have been synthesized. Their receptor binding profiles (5‐HT1A, 5‐HT1B) and analgesic activity (hot plate, acetic acid induced writhing) have been studied. The analgesic activity of compounds 7d, 8b, 8c, and 8e are at least comparable to that of the clinically used drugs flupirtine and tramadol under the same conditions.

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“…In publication [19] a detailed study of quin vibrational spectra was carried out. Quin is widely studied in drug research for use as antimalarials [20,21], antitumor agents [22] and for a treatment of HIV [23].…”

Section: Introductionmentioning

confidence: 99%

Novel Salts of 2,4-Diaminoquinazoline: Searching for Materials for Second Harmonic Generation Based on a Promising Polarizable Cation

et al. 2012

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The chloride and L-tartrate salts of the 2,4-diaminoquinazolinium(1?) were prepared and characterized by both X-ray diffraction and infrared spectroscopy. The potential of the 2,4-diaminoquinazolinium(1?) cation as a building block for materials for nonlinear optics was assessed using quantum mechanical computations. Both 2,4-diaminoquinazolinium(1?) chloride dihydrate (a = 7.2121 (1) Å , b = 8.0105(2) Å , c = 18.6157(5) Å , b = 92.493(1)°, V = 1074.46(4) Å 3 , Z = 4, R = 0.0305 for 4605 observed reflections) and 2,4-diaminoquinazolinium(1?) L-tartrate dihydrate (a = 7.2899(2) Å , b = 11.9508(2) Å , c = 13.4 183(3) Å , b = 92.375(2)°, V = 1168.00(5) Å 3 , Z = 2, R = 0.0367 for 4761 observed reflections) belong to the monoclinic space group P2 1 . They are stable, nonhygroscopic, colorless and exhibit non-zero SHG efficiency for powdered samples.

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151. Synthetic antimalarials. Part XIV. Some 2-arylamino-4-aminoalkylaminoquinazolines

Cited by 31 publications

References 0 publications

Quinoxaline and Arylaminoalcohol Derivatives as Antiplasmodial and Leishmanicidal Agents: A Review of our First Ten Years in the Field

Quinoxaline and Arylaminoalcohol Derivatives as Antiplasmodial and Leishmanicidal Agents: A Review of our First Ten Years in the Field

Synthesis and Analgesic Activity of Some Condensed Analogs of Anpirtoline

Novel Salts of 2,4-Diaminoquinazoline: Searching for Materials for Second Harmonic Generation Based on a Promising Polarizable Cation

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