150 years of the periodic table: New medicines and diagnostic agents

Imberti, Cinzia; Sadler, Peter J.

doi:10.1016/bs.adioch.2019.11.001

Cited by 20 publications

(9 citation statements)

References 248 publications

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“…In addition to improvements in platinum drugs, intensive research has aimed to develop new complexes using other metal ions (copper, nickel, gold, ruthenium, osmium, and palladium). Several recent reviews focus on these attempts at new metal-based drug design, e.g., ruthenium-, osmium-, and palladium-based molecules [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Nickel(II), Palladium(II), and Platinum(II) Complexes with O,S Bidendate Cinnamic Acid Ester Derivatives: An In Vitro Cytotoxic Comparison to Ruthenium(II) and Osmium(II) Analogues

Hildebrandt

Häfner

Görls

et al. 2022

IJMS

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(1) Background: Since the discovery of cisplatin’s cytotoxic properties, platinum(II) compounds have attracted much interest in the field of anticancer drug development. Over the last few years, classical structure–activity relationships (SAR) have been broken by some promising new compounds based on platinum or other metals. We focus on the synthesis and characterization of 17 different complexes with β-hydroxydithiocinnamic acid esters as O,S bidendate ligands for nickel(II), palladium(II), and platinum(II) complexes. (2) Methods: The bidendate compounds were synthesized and characterized using classical methods including NMR spectroscopy, MS spectrometry, elemental analysis, and X-ray crystallography, and their cytotoxic potential was assessed using in vitro cell culture assays. Data were compared with other recently reported platinum(II), ruthenium(II), and osmium(II) complexes based on the same main ligand system. (3) Results: SAR analyses regarding the metal ion (M), and the alkyl-chain position (P) and length (L), revealed the following order of the effect strength for in vitro activity: M > P > L. The highest activities have Pd complexes and ortho-substituted compounds. Specific palladium(II) complexes show lower IC50 values compared to cisplatin, are able to elude cisplatin resistance mechanisms, and show a higher cancer cell specificity. (4) Conclusion: A promising new palladium(II) candidate (Pd3) should be evaluated in further studies using in vivo model systems, and the identified SARs may help to target platinum-resistant tumors.

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Section: Introductionmentioning

confidence: 99%

Novel Nickel(II), Palladium(II), and Platinum(II) Complexes with O,S Bidendate Cinnamic Acid Ester Derivatives: An In Vitro Cytotoxic Comparison to Ruthenium(II) and Osmium(II) Analogues

Hildebrandt

Häfner

Görls

et al. 2022

IJMS

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“…Lesson number one focused on the Chemical Elements and the Periodic Table, in order to celebrate the 150th anniversary of the Periodic Table of Chemical Elements and also the "International Year of the Periodic Table of Chemical Elements (IYPT2019)" declared by the United Nations General Assembly and UNESCO. The development of the Periodic Table of Chemical Elements is one of the most significant achievements in science and a consolidating scientific concept with broad implications in chemistry, physics, biology and other sciences (Imberti & Sadler, 2020;Semenova, Tarasov, & Goodilin, 2019). Consolidate, deepen and expand knowledge by understanding concepts related to the Periodic Table provides the students a solid base of knowledge of chemistry and science values.…”

Section: Project Descriptionmentioning

confidence: 99%

Molecular School – a pre-university chemistry school

Nogueira

Silva

Mendes

et al. 2021

Chemistry Teacher International

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The planning, implementation and results of the first edition of the Molecular School are presented, as the first pre-university school project held in Portugal. This is not, however, a strictly Portuguese project, since it can be replicated in other countries at the secondary school level, with minor adjustments. Herein, the pilot edition of Molecular School is detailed and discussed, where 36 secondary school students have participated. The plan for the second edition, to be held in the first semester of 2021, with the confirmed participation of around 100 students, is further presented. Briefly, the project is divided in two modules: theoretical and laboratory work. These were prepared in a complementary way and performed to achieve the same purpose: deliver a wider vision of what chemistry really is. Hence, the classes were designed having in mind the applications that chemistry has in our everyday life, in the different academic research fields and in industry. A better preparation and training at the laboratory level was also a goal of this project. The enthusiasm, happiness and the motivation shown by the students, and their eagerness to participate in the future editions of the Molecular School, were clear signs of this project success.

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“…Ruthenium(II)-arene complexes of the type [(η 6 -arene)Ru(N ∧ N)Cl] + , where N ∧ N = N, N-donor chelating ligands with sulfonamide substituents of various steric and electronic properties, catalyze the hydride transfer reaction to NAD + in the presence of formate, glycerol, isopropanol, and hydrogen as its source ( Soldevilla-Barreda et al, 2015 ; Chen et al, 2018 ). Thus, these complexes can catalytically reduce NAD + to NADH, inducing reductive stress by controlling the [NAD + ]/[NADH] ratio ( Soldevilla-Barreda et al, 2015 ; Chen et al, 2018 ; Chrzanowska et al, 2020a ; Inverti and Sadler, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Many of them are not soluble in an aqueous solution. Moreover, they are not stable in aqueous solutions, they need to be generated in situ , unlike non-organometallic Ru(II) complexes, which can be prepared and isolated in advance ( Betanzos-Lara et al, 2013 ; Chrzanowska et al, 2020a ; Inverti and Sadler, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Reactivity of non-organometallic ruthenium(II) polypyridyl complexes and their application as catalysts for hydride transfer reactions

Chrzanowska

Katafias²,

Eldik³

2023

Front. Chem.

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Recently, we investigated the substitution behavior of a series of ruthenium(II) complexes of the general formula [RuII(terpy)(N∧N)Cl]Cl, where terpy = 2,2′:6′,2″-terpyridine, N∧N = bidentate ligand, in aqueous solutions. We have shown that the most and least reactive complexes of the series are [RuII(terpy)(en)Cl]Cl (en = ethylenediamine) and [RuII(terpy)(phen)Cl]Cl (phen = 1, 10-phenantroline), respectively, as a result of different electronic effects provided by the bidentate spectator chelates. Polypyridyl amine Ru(II) complex, viz. [Ru(terpy)(en)Cl]Cl and [Ru(terpy)(ampy)Cl]Cl (where ampy = 2-(aminomethyl)pyridine), in which the terpy chelate labilizes the metal center, are able to catalyze the conversion of NAD+ to 1,4-NADH using sodium formate as a source of hydride. We showed that this complex can control the [NAD+]/[NADH] ratio and potentially induce reductive stress in living cells, which is accepted as an effective method to kill cancer cells. Polypyridyl Ru(II) complexes, characterized in terms of the behavior in aqueous solutions, can be used as model systems to monitor heterogeneous multiphase ligand substitution reactions at the solid-liquid interface. Colloidal coordination compounds in the submicron range were synthesized from Ru(II)-aqua derivatives of starting chlorido complexes via the anti-solvent procedure and stabilized by a surfactant shell layer.

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150 years of the periodic table: New medicines and diagnostic agents

Cited by 20 publications

References 248 publications

Novel Nickel(II), Palladium(II), and Platinum(II) Complexes with O,S Bidendate Cinnamic Acid Ester Derivatives: An In Vitro Cytotoxic Comparison to Ruthenium(II) and Osmium(II) Analogues

Novel Nickel(II), Palladium(II), and Platinum(II) Complexes with O,S Bidendate Cinnamic Acid Ester Derivatives: An In Vitro Cytotoxic Comparison to Ruthenium(II) and Osmium(II) Analogues

Molecular School – a pre-university chemistry school

Reactivity of non-organometallic ruthenium(II) polypyridyl complexes and their application as catalysts for hydride transfer reactions

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