150 years ago: First complete removal of the larynx by Theodor Billroth

Mudry, Albert; Laccourreye, O.

doi:10.1016/j.anorl.2022.10.001

Cited by 25 publications

(4 citation statements)

References 2 publications

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“…This year, 2023, is the 150th anniversary of the first TL surgery, which was performed in humans on the final day of 1873 by Theodor Billroth. 17,18 After years of clinical experience, TL have been confirmed to be a valuable therapeutic method in patients with laryngeal or hypopharyngeal cancer for whom no organ-sparing protocol is available. 19 However, the problem of complications is arising in parallel with the increasing use of TL.…”

Section: Discussionmentioning

confidence: 99%

Transnasal negative pressure therapy for accelerating healing and improving the prognosis of pharyngocutaneous fistula

Hu,

Guo,

Chen

et al. 2023

Head & Neck

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BackgroundPharyngocutaneous fistula (PCF) is one of the most common complications of total laryngectomy. This study is to investigate the efficacy of a novel platform called transnasal negative pressure therapy (TNPT) in the management of PCF.MethodsWe retrospectively reviewed 47 patients who underwent total laryngectomy between April 2015 and February 2021 and developed PCF in our hospital. We focused on the healing rate, dressing change frequency, and healing time between the TNPT and non‐TNPT groups. The 2 years overall survival (OS) was compared through the log‐rank test.ResultsThere were 18 patients in the TNPT group and 29 in the non‐TNPT group. There was no significant between‐group difference in the healing rate (chi‐square test). However, the frequency of dressing changes was significantly lower (p < 0.001) and the healing time was significantly shorter (p = 0.0194) in the TNPT group than in the non‐TNPT group. The 2‐year OS rate was significantly higher in the TNPT group (p = 0.0473, log‐rank test).ConclusionTNPT promoted wound healing after surgery for PCF and improved the 2‐year OS rate. This tool is worthy of clinical application and promotion.

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Section: Discussionmentioning

confidence: 99%

Transnasal negative pressure therapy for accelerating healing and improving the prognosis of pharyngocutaneous fistula

Hu,

Guo,

Chen

et al. 2023

Head & Neck

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“…The first two concern the single-center and retrospective design, a limitation however found in almost all the 21st century literature on TL. [8][9][10][11]18,[21][22][23][24][25][26][27][28][29][30][31][32][33][34] The third, and doubtless most important, point concerns to a variety of treatments detailed in the section describing the study population (Table I), with TL performed by 54 different headand-neck surgeons (see Acknowledgments) over a period of 4 decades. However, the local recurrence rate seemed not to vary from decade to decade (Table II), relativizing this bias and suggesting that oncologic results, and notably local recurrence, after TL for endolaryngeal cT3-4 SCC are not operator-dependent.…”

Section: Discussionmentioning

confidence: 99%

“…Like all reports following the STROBE guideline, 12 this discussion ends with study biases and three points limiting the scope of our conclusions. The first two concern the single‐center and retrospective design, a limitation however found in almost all the 21st century literature on TL 8–11,18,21–34 . The third, and doubtless most important, point concerns to a variety of treatments detailed in the section describing the study population (Table I), with TL performed by 54 different head‐and‐neck surgeons (see Acknowledgments) over a period of 4 decades.…”

Section: Discussionmentioning

confidence: 99%

“…On this 150th anniversary of the first description of TL, 11 confronted by this gap in the data, we performed a retrospective observational study using the STROBE guideline 12 in an inception cohort of 531patients with isolated untreated endolaryngeal cT3‐4M0 SCC, consecutively managed by primary TL in a French university teaching hospital otorhinolaryngology head & neck surgery department between 1970 and 2012. The main objective was to determine the 10‐year actuarial local control estimate.…”

Section: Introductionmentioning

confidence: 99%

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Primary Total Laryngectomy for Endolaryngeal cT3‐4M0 Squamous Cell Carcinoma: A STROBE Analysis

Laccourreye,

Garcia,

Haroun

et al. 2023

The Laryngoscope

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ObjectivesTo document 10‐year oncologic outcome of primary total laryngectomy (TL) for patients with cT3‐4M0 endolaryngeal squamous cell carcinoma (SCC).Study DesignObservational inception cohort of 531 patients with isolated untreated endolaryngeal cT3‐4M0 SCC review over 40 years using STROBE guideline. 94% of patients were followed until death or for a minimum of 10 years.SettingAcademic tertiary referral care center.MethodsAll patients underwent primary TL. Prior tracheotomy, induction chemotherapy, thyroid gland resection, level II‐IV neck dissection, level VI dissection, and postoperative radiation therapy were associated in 6%, 40%, 43%, 89%, 47%, and 74% of cases, respectively: The main objective was to determine the 10‐year actuarial local control estimate. Accessory objectives comprised screening for clinical variables increasing the risk of local recurrence, and analysis of long‐term oncologic consequences of local recurrence.ResultsThe 10‐year actuarial local control estimate was 89.7%. Local recurrence was salvaged in 11% of cases, resulting in 92% overall local control. On multivariate analysis, none of the study variables correlated with local recurrence. Local recurrence resulted in significantly reduced nodal control, distant metastasis control, and survival. Postoperative complications, persistent index SCC, intercurrent disease, and metachronous second primary cancer accounted for respectively 3%, 37%, 33%, and 28% of the 334 deaths noted during the 10 years following TL.ConclusionThe present study underscored the long‐term oncologic efficacy of primary TL, the dangers of local recurrence, the key role of local control for survival, and the importance of a long‐term oncologic watch policy.Level of Evidence3 Laryngoscope, 2023

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Unlocking tracheoesophageal speech from pharyngoesophageal spasm: preliminary results of a videofluoroscopic-guided botulinum toxin A injection technique

Bandi,

Chu,

Zurlo

et al. 2024

Eur Arch Otorhinolaryngol

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150 years ago: First complete removal of the larynx by Theodor Billroth

Cited by 25 publications

References 2 publications

Transnasal negative pressure therapy for accelerating healing and improving the prognosis of pharyngocutaneous fistula

Transnasal negative pressure therapy for accelerating healing and improving the prognosis of pharyngocutaneous fistula

Primary Total Laryngectomy for Endolaryngeal cT3‐4M0 Squamous Cell Carcinoma: A STROBE Analysis

Unlocking tracheoesophageal speech from pharyngoesophageal spasm: preliminary results of a videofluoroscopic-guided botulinum toxin A injection technique

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