15-Lipoxygenase-1 in the Vasculature

Mochizuki, Naoki; Kwon, Young Guen

doi:10.1161/circresaha.107.170191

Cited by 18 publications

(15 citation statements)

References 21 publications

(37 reference statements)

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“…Anti-angiogenic actions of 15-lipoxygenase on angiogenesis is regulated by PPAR γ and VEGF by inhibiting the expression of VEGFR2 in endothelial cells (Mochizuki and Kwon, 2008; Viita et al, 2008). Because the chemical PPAR γ ligands thiazolidinediones have been used widely for the treatment of type 2 diabetic patients, many of whom experience vascular diseases, clarifying the precise role of PPAR γ in defective placental angiogenesis may be of clinical significance.…”

Section: Downstream Targets Of Homeobox Genesmentioning

confidence: 99%

Analysis of homeobox gene action may reveal novel angiogenic pathways in normal placental vasculature and in clinical pregnancy disorders associated with abnormal placental angiogenesis.

2014

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Homeobox genes are essential for both the development of the blood and lymphatic vascular systems, as well as for their maintenance in the adult. Homeobox genes comprise an important family of transcription factors, which are characterized by a well conserved DNA binding motif; the homeodomain. The specificity of the homeodomain allows the transcription factor to bind to the promoter regions of batteries of target genes and thereby regulates their expression. Target genes identified for homeodomain proteins have been shown to control fundamental cell processes such as proliferation, differentiation, and apoptosis. We and others have reported that homeobox genes are expressed in the placental vasculature, but our knowledge of their downstream target genes is limited. This review highlights the importance of studying the cellular and molecular mechanisms by which homeobox genes and their downstream targets may regulate important vascular cellular processes such as proliferation, migration, and endothelial tube formation, which are essential for placental vasculogenesis and angiogenesis. A better understanding of the molecular targets of homeobox genes may lead to new therapies for aberrant angiogenesis associated with clinically important pregnancy pathologies, including fetal growth restriction and preeclampsia.

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Section: Downstream Targets Of Homeobox Genesmentioning

confidence: 99%

Analysis of homeobox gene action may reveal novel angiogenic pathways in normal placental vasculature and in clinical pregnancy disorders associated with abnormal placental angiogenesis.

2014

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“…15-LOX-1 exerted anti-angiogenic effects by inhibiting vascular endothelial growth factor-A and placental growth factor in a rabbit skeletal muscle experimental model [71]. However, the role of 15-LOX-1 in angiogenesis during tumorigenesis remains controversial [12,72]. In one model, 15-LOX-1 re-expression in PC-3 prostatic cancer cells increased vascular epidermal growth factor in vitro and angiogenesis in subcutaneous xenografts [73].…”

Section: 15-lox-1 and Colon Tumorigenesismentioning

confidence: 99%

15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?

Lee

Zuo

Shureiqi

2011

Cancer Metastasis Rev

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15-Lipoxygenase-1 (15-LOX-1) is an inducible and highly regulated enzyme in normal human cells that plays a key role in the production of lipid signaling mediators, such as 13-hydroxyoctadecadienoic acid (13-HODE) from linoleic acid. 15-LOX-1 significantly contributes to resolution of inflammation and to terminal differentiation of normal cells. 15-LOX-1 is downregulated in human colorectal polyps and cancers. Emerging data support a tumor suppressor role for 15-LOX-1, especially in colon cancer. These data indicate that 15-LOX-1 promotes various antitumorigenic events, including cell differentiation and apoptosis, and inhibits chronic inflammation, angiogenesis, and metastasis. The transcriptional repression of 15-LOX-1 in colon cancer cells is complex and involves multiple mechanisms (e.g., histone methylation, transcriptional repressor binding). Re-expression of 15-LOX-1 in colon cancer cells can function as an important therapeutic mechanism and could be further exploited to develop novel treatment approaches for this common cancer.

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“…Available data suggest that lipoxygenases contribute to in vivo metabolism of endobiotics and xenobiotics in mammals (Kulkarni, 2001). Recent reviews describe the role of lipoxygenase in cancer (Bhattacharya et al, 2009;Pidgeon et al, 2007;Moreno, 2009), inflammation (Duroudier et al, 2009;Hersberger, 2010) and vascular biology (Chawengsub et al, 2009;Mochizuki & Kwon, 2008) and for an extensive presentation of the role of eicosanoids in prevention and management of diseases the reader is referred to the review of Szefel et al (2011).…”

Section: In Humansmentioning

confidence: 99%

Inhibition of Soybean Lipoxygenases – Structural and Activity Models for the Lipoxygenase Isoenzymes Family

Chedea¹,

Jisaka²

2011

Recent Trends for Enhancing the Diversity and Quality of Soybean Products

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15-Lipoxygenase-1 in the Vasculature

Cited by 18 publications

References 21 publications

Analysis of homeobox gene action may reveal novel angiogenic pathways in normal placental vasculature and in clinical pregnancy disorders associated with abnormal placental angiogenesis.

Analysis of homeobox gene action may reveal novel angiogenic pathways in normal placental vasculature and in clinical pregnancy disorders associated with abnormal placental angiogenesis.

15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?

Inhibition of Soybean Lipoxygenases – Structural and Activity Models for the Lipoxygenase Isoenzymes Family

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