15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia

Xu, Yunfei; Qiao, Haoduo; Yang, Shun Fa; Zhang, Lin; Zhao, Yao; Xu, Qing; Miao, Shuying; Yuan, Dejian; Zhao, Jie; Liu, Ying

doi:10.3389/fneur.2022.893624

Cited by 3 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We could not adjust for the NIHSS in this study due to its unavailability. This limitation has been noted in previous research as well ( 38 , 39 ). To address this, we used the GCS as alternative way to estimate stroke severity.…”

Section: Discussionmentioning

confidence: 69%

Assessing the predictive value of neutrophil percentage to albumin ratio for ICU admission in ischemic stroke patients

Zawiah,

Khan,

Farha

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

BackgroundAcute ischemic stroke (AIS) remains a substantial global health challenge, contributing to increased morbidity, disability, and mortality. This study aimed at investigating the predictive value of the neutrophil percentage to albumin ratio (NPAR) in determining intensive care unit (ICU) admission among AIS patients.MethodsA retrospective observational study was conducted, involving AIS cases admitted to a tertiary hospital in Jordan between 2015 and 2020. Lab data were collected upon admission, and the primary outcome was ICU admission during hospitalization. Descriptive and inferential analyses were performed using SPSS version 29.ResultsIn this study involving 364 AIS patients, a subset of 77 (21.2%) required admission to the ICU during their hospital stay, most frequently within the first week of admission. Univariable analysis revealed significantly higher NPAR levels in ICU-admitted ischemic stroke patients compared to those who were not admitted (23.3 vs. 15.7, p < 0.001), and multivariable regression models confirmed that higher NPAR (≥19.107) independently predicted ICU admission in ischemic stroke patients (adjusted odds ratio [aOR] = 4.85, 95% CI: 1.83–12.83). Additionally, lower GCS scores and higher neutrophil-to-lymphocyte ratio (NLR) were also associated with increased likelihood of ICU admission. In terms of predictive performance, NPAR showed the highest accuracy with an AUC of 0.885, sensitivity of 0.805, and specificity of 0.854, using a cutoff value of 19.107. NPAR exhibits an AUC of 0.058, significantly outperforming NLR (Z = 2.782, p = 0.005).ConclusionNPAR emerged as a robust independent predictor of ICU admission in ischemic stroke patients, surpassing the predictive performance of the NLR.

show abstract

Section: Discussionmentioning

confidence: 69%

Assessing the predictive value of neutrophil percentage to albumin ratio for ICU admission in ischemic stroke patients

Zawiah,

Khan,

Farha

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

show abstract

Predictors of stroke-associated pneumonia and the predictive value of neutrophil percentage-to-albumin ratio

Zawiah,

Khan,

Abu Farha

et al. 2023

Postgraduate Medicine

View full text Add to dashboard Cite

Reduced plasma levels of RGM-A predict stroke-associated pneumonia in patients with acute ischemic stroke: A prospective clinical study

et al. 2022

View full text Add to dashboard Cite

Background: Stroke-induced immunodepression syndrome is considered the major etiology of stroke-associated pneumonia (SAP). Repulsive guidance molecule A (RGM-A) is an immunomodulatory protein that is closely related to inflammation and immune responses. To explore the relationship between RGM-A and SAP and facilitate the early identification of patients at high risk of developing SAP, we investigated the predictive value of RGM-A in SAP. Methods:We enrolled patients with acute ischemic stroke (AIS) and finally analyzed patients, among whom had SAP and had non-SAP. During the same period, patients with community-acquired pneumonia and healthy participants were included as controls. SAP was defined according to the modified US Centers for Disease Control and Prevention criteria. Blood samples were collected at h, h, days, to days, and to days after stroke onset. An enzyme-linked immunosorbent assay was used to detect the plasma levels of RGM-A and interleukin-. Results:The plasma RGM-A levels were significantly decreased in both patients with community-acquired pneumonia and those with AIS, and the decline was most pronounced in patients with SAP (P < .). RGM-A started to decline within h after stroke in the SAP group, and the lowest levels were detected on day and days to (P < .). The RGM-A levels in the SAP group were lower than those in the non-SAP group at all blood collection time points (P < . ). In the logistic regression analyses, RGM-A was a protective factor for SAP after adjusting for confounders (adjusted odds ratio = . , % confidence interval = .-. , P = .

show abstract

15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia

Cited by 3 publications

References 28 publications

Assessing the predictive value of neutrophil percentage to albumin ratio for ICU admission in ischemic stroke patients

Assessing the predictive value of neutrophil percentage to albumin ratio for ICU admission in ischemic stroke patients

Predictors of stroke-associated pneumonia and the predictive value of neutrophil percentage-to-albumin ratio

Reduced plasma levels of RGM-A predict stroke-associated pneumonia in patients with acute ischemic stroke: A prospective clinical study

Contact Info

Product

Resources

About