15,16-Dihydrotanshinone I suppresses IgE-Ag stimulated mouse bone marrow-derived mast cell activation by inhibiting Syk kinase

Li, Xian; Yang, Ju Hye; Jin, Yufeng; Jin, Fansi; Kim, Dong‐Young; Chang, Jae‐Hoon; Kim, Jung-Ae; Son, Jong‐Keun; Moon, Tae Chul; Son, Kun Ho; Chang, Hyeun Wook

doi:10.1016/j.jep.2015.04.022

Cited by 10 publications

(8 citation statements)

References 35 publications

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“…Two groups of the major representative constituents were been isolated from Danshen, which are hydrophilic phenolic acids and lipophilic diterpene quinones, containing danshensu (DSS), protocatechuic aldehyde (PAL), rosmarinic acid (RA), lithospermic acid, salvianolic acid B (SAB), dihydrotanshinone I (DI), cryptotanshinone (CT), tanshinone I (TI), and tanshinone IIA (IIA). Modern pharmacological studies have indicated that these chemicals have various biological activities, such as anti-myocardial ischemia [ 5 ], anti-cerebral ischemia [ 6 , 7 ], anti-atherosclerosis [ 8 ], anti-tumor [ 9 , 10 , 11 ], anti-thrombosis [ 12 ], anti-hepatocyte injury [ 13 , 14 ], renal protecting [ 15 ], anti-inflammatory [ 16 , 17 , 18 ], etc. The synergistic action of these various components is considered to be responsible for the therapeutic effects of Danshen.…”

Section: Introductionmentioning

confidence: 99%

Quality Evaluation and Chemical Markers Screening of Salvia miltiorrhiza Bge. (Danshen) Based on HPLC Fingerprints and HPLC-MSn Coupled with Chemometrics

Liang

Chen

et al. 2017

Molecules

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Danshen, the dried root of Salvia miltiorrhiza Bge., is a widely used commercially available herbal drug, and unstable quality of different samples is a current issue. This study focused on a comprehensive and systematic method combining fingerprints and chemical identification with chemometrics for discrimination and quality assessment of Danshen samples. Twenty-five samples were analyzed by HPLC-PAD and HPLC-MSn. Forty-nine components were identified and characteristic fragmentation regularities were summarized for further interpretation of bioactive components. Chemometric analysis was employed to differentiate samples and clarify the quality differences of Danshen including hierarchical cluster analysis, principal component analysis, and partial least squares discriminant analysis. Consistent results were that the samples were divided into three categories which reflected the difference in quality of Danshen samples. By analyzing the reasons for sample classification, it was revealed that the processing method had a more obvious impact on sample classification than the geographical origin, it induced the different content of bioactive compounds and finally lead to different qualities. Cryptotanshinone, trijuganone B, and 15,16-dihydrotanshinone I were screened out as markers to distinguish samples by different processing methods. The developed strategy could provide a reference for evaluation and discrimination of other traditional herbal medicines.

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Section: Introductionmentioning

confidence: 99%

Quality Evaluation and Chemical Markers Screening of Salvia miltiorrhiza Bge. (Danshen) Based on HPLC Fingerprints and HPLC-MSn Coupled with Chemometrics

Liang

Chen

et al. 2017

Molecules

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“…Both RS and DS ethanolic extracts exhibited pharmacological effects on the "Spleen" ex vivo irrespective of their difference in chemical composition. Active P. K. Leong et al DOI: 10.4236/cm.2019.104007components of DS, such as salvianolic acids, tanshinones and dihydrotanshinone, have been shown to produce immunomodulatory actions[17] [18] [19], which may be related to an enhancement of "Spleen" function. Given that no common chemical constituents have been identified in RS and DS[20] [21], the active component(s) in DS responsible for eliciting the organ-specific response is yet to be determined.…”

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confidence: 99%

Pharmacological Investigation of “Meridian Tropism” in Three “Shen” Chinese Herbs

Leong¹,

Leung²,

Chan³

et al. 2019

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"Meridian tropism" refers to the organ-specific biological action(s) produced by a Chinese herb following its oral administration, which is analogous to the concept of "bioavailability" in Western medicine. In this study, we compared the in vitro and ex vivo pharmacological actions of three herbs [namely, Dangshen (DS, Codonopsis Radix), Ranshen (RS, Ginseng Radix) and Xiyangshen (XYS, Panacis Qinquifolii Ra-dix)] to validate their meridian tropism. We compared the in vitro and ex vivo pharmacological actions [i.e. the ability to increase splenocyte proliferation and adenosine triphosphategeneration capacity (ATP-GC)] of the ethanolic extracts of DS, RS and XYS to validate their meridian tropism. Results showed that DS, RS and XYS (at 30-300 μg/mL) can both stimulate the proliferation of primary mouse splenocytes in vitro and increase adenosine triphosphate-generation capacity (ATP-GC) in cultured Caco 2 colon epithelial cells in vitro. Interestingly, oral administration of DS and RS (but not XYS, at 3 and 6 g/kg/day × 3 consecutive days) was found to stimulate the proliferation of splenocytes ex vivo at 24 h post-treatment in mice. Similarly, DS and RS (but not XYS) increased the ATP-GC of mitochondrial fractions isolated from a small segment of mouse intestine at 48 h post-treatment. This observation is consistent with the meridian tropism of the pharmacological action of "Shen", i.e., the accessibility of DS and RS (but not XYS) to the "Spleen" meridian. The comparison between the results obtained from in vitro and in vivo/ex vivo bioassays may offer a potential method for assessing meridian tropism in Chinese herbs.

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“…Salvia miltiorrhiza is a perennial herb which is well known to have tanshinones as principal bioactives. This plant is widely employed as traditional remedy, particularly in TCM (Li et al, 2015). Over the past decade, researchers have conducted studies to investigate its anti-allergic effect.…”

Section: Inhibition Of Allergen-specific Igementioning

confidence: 99%

“…Additionally, the ethanolic extract of S. miltiorrhiza also inhibited other chemical mediators, such as leukotriene C 4 with a IC 50 value of 2.6 µg/ml, COX-1 and COX-2-dependent prostaglandin D 4 with IC 50 values of 3.96 and 21.54 µg/ml respectively (Yang et al, 2008). With the aid of findings from Yang et al (2008), Li et al (2015) successfully identified 15,16-dihydrotanshinone-I (7) as the compound responsible for the inhibition of intracellular calcium level, hence suppressing the downstream release of leukotriene C 4 and prostaglandin D 4 from activated bone marrow-derived mast cells (BMMC). The inhibition percentage achieved was as high as 90% with a dose of 20 µM of 15,16-dihydrotanshinone-I (7) (Li et al, 2015).…”

Section: Inhibition Of Allergic Mediators and Secretory Granulesmentioning

confidence: 99%

“…With the aid of findings from Yang et al (2008), Li et al (2015) successfully identified 15,16-dihydrotanshinone-I (7) as the compound responsible for the inhibition of intracellular calcium level, hence suppressing the downstream release of leukotriene C 4 and prostaglandin D 4 from activated bone marrow-derived mast cells (BMMC). The inhibition percentage achieved was as high as 90% with a dose of 20 µM of 15,16-dihydrotanshinone-I (7) (Li et al, 2015).…”

Section: Inhibition Of Allergic Mediators and Secretory Granulesmentioning

confidence: 99%

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Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action

2019

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The prevalence of allergic diseases such as asthma, allergic rhinitis, food allergy and atopic dermatitis has increased dramatically in recent decades. Conventional therapies for allergy can induce undesirable effects and hence patients tend to seek alternative therapies like natural compounds. Considering the fact above, there is an urgency to discover potential medicinal plants as future candidates in the development of novel anti-allergic therapeutic agents. The Lamiaceae family, or mint family, is a diverse plant family which encompasses more than 7,000 species and with a cosmopolitan distribution. A number of species from this family has been widely employed as ethnomedicine against allergic inflammatory skin diseases and allergic asthma in traditional practices. Phytochemical analysis of the Lamiaceae family has reported the presence of flavonoids, flavones, flavanones, flavonoid glycosides, monoterpenes, diterpenes, triterpenoids, essential oil and fatty acids. Numerous investigations have highlighted the anti-allergic activities of Lamiaceae species with their active principles and crude extracts. Henceforth, this review has the ultimate aim of compiling the up-to-date (2018) findings of published scientific information about the anti-allergic activities of Lamiaceae species. In addition, the botanical features, medicinal uses, chemical constituents and toxicological studies of Lamiaceae species were also documented. The method employed for data collection in this review was mainly the exploration of the PubMed, Ovid and Scopus databases. Additional research studies were obtained from the reference lists of retrieved articles. This comprehensive summarization serves as a useful resource for a better understanding of Lamiaceae species. The anti-allergic mechanisms related to Lamiaceae species are also reviewed extensively which aids in future exploration of the anti-allergic potential of Lamiaceae species.

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15,16-Dihydrotanshinone I suppresses IgE-Ag stimulated mouse bone marrow-derived mast cell activation by inhibiting Syk kinase

Cited by 10 publications

References 35 publications

Quality Evaluation and Chemical Markers Screening of Salvia miltiorrhiza Bge. (Danshen) Based on HPLC Fingerprints and HPLC-MSn Coupled with Chemometrics

Quality Evaluation and Chemical Markers Screening of Salvia miltiorrhiza Bge. (Danshen) Based on HPLC Fingerprints and HPLC-MSn Coupled with Chemometrics

Pharmacological Investigation of “Meridian Tropism” in Three “Shen” Chinese Herbs

Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action

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