2019
DOI: 10.1134/s107042801902012x
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14β-(Isoxazol-3-yl)methylestrane Steroids: Chemoselective Synthesis and Transformations with Heterocyclic Ring Opening

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Cited by 6 publications
(1 citation statement)
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“…Chemical modification of natural steroids with different heterocycles provides a way to alter the function of the parent compound, and several derivatives have been demonstrated to be effective in the prevention and treatment of many types of cancers [ 11 ]. Although there are no examples in the literature for the synthesis of steroidal benzisoxazoles, the incorporation of the five-membered isoxazole ring into a sterane backbone in either a connected [ 12 , 13 , 14 ] or a condensed manner [ 15 ] led to some effective antiproliferative agents ( I – VIII , Figure 1 ). Nevertheless, the phenolic A-ring of estrogens offers the possibility to synthesize aromatic ring-integrated benzisoxazole hybrids and this modification may have beneficial outcomes in several aspects.…”
Section: Introductionmentioning
confidence: 99%
“…Chemical modification of natural steroids with different heterocycles provides a way to alter the function of the parent compound, and several derivatives have been demonstrated to be effective in the prevention and treatment of many types of cancers [ 11 ]. Although there are no examples in the literature for the synthesis of steroidal benzisoxazoles, the incorporation of the five-membered isoxazole ring into a sterane backbone in either a connected [ 12 , 13 , 14 ] or a condensed manner [ 15 ] led to some effective antiproliferative agents ( I – VIII , Figure 1 ). Nevertheless, the phenolic A-ring of estrogens offers the possibility to synthesize aromatic ring-integrated benzisoxazole hybrids and this modification may have beneficial outcomes in several aspects.…”
Section: Introductionmentioning
confidence: 99%