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Konstantinidou, Anastasia; Korkolopoulou, Penelope; Patsouris, Efstratios; Mahera, H; Hranioti, Stavroula; Kotsiakis, Xenophon; Davaris, Panagiotis

doi:10.1023/a:1012941202510

Cited by 18 publications

(8 citation statements)

References 27 publications

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“…Malignant potential of meningiomas can be evaluated using several cytokinetic markers, such as PI or apoptotic index [8]. While PI has no prognostic significance in BM [15], several studies have shown a correlation between PI and prognosis of patients with AMM [5, 16].…”

Section: Discussionmentioning

confidence: 99%

“…While PI has no prognostic significance in BM [15], several studies have shown a correlation between PI and prognosis of patients with AMM [5, 16]. Apoptotic index shows correlation with PI and tendency to rise with meningioma grade [8]. Prognostic implication of apoptosis in meningioma recurrence has been proposed [8].…”

Section: Discussionmentioning

confidence: 99%

“…Accelerating apoptosis in vitro can slow tumor growth, including meningioma growth [6]. Mistakes in the apoptosis mechanism are present meningioma cells [7, 8]. …”

Section: Introductionmentioning

confidence: 99%

“…Positive correlation between apoptotic index (AI) and proliferation index (PI) was shown in meningiomas [8]. AI was also found to be a predictor of meningioma recurrence [8].…”

Section: Introductionmentioning

confidence: 99%

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Caspase-3 and Survivin Expression in Primary Atypical and Malignant Meningiomas

Vranic

2013

ISRN Neuroscience

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Objective. Information about possible prognostic factors of the survival of patients with atypical and malignant meningiomas (AMM) is sparse. The aim of our study was to evaluate prognostic significance of apoptotic marker caspase-3 and apoptotic inhibitor survivin in a series of primary AMM. Methods. 86 AMM (76 atypical and 10 malignant) were analyzed. Caspase-3 and survivin expression was evaluated immunohistochemically. The correlation between caspase-3, survivin, and other possible factors of meningioma recurrence was evaluated. Uni- and multivariate recurrence-free survival (RFS) and overall survival (OS) analyses were performed. Results. The intensity of caspase-3 expression correlated with the tumor grade (P = 0.004), the proliferation index (P = 0.019), and the mitotic count (P = 0.013). Survivin tended to be more expressed in female patients (P = 0.072). Survivin expression was stronger in malignant compared to atypical meningiomas, however, the difference was not statistically important (P = 0.491). Neither survivin nor caspase-3 expression significantly predicted OS or RFS in patients with AMM. Conclusions. Strong caspase-3 expression on AMM cells could reflect a cellular attempt at the homeostatic autoregulation of the tumor size. Survivin expression on AMM cells is similar to the survivin expression reported on benign meningiomas. Caspase-3 and survivin expression has no prognostic significance on the survival of patients with AMM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Accelerating apoptosis in vitro can slow tumor growth, including meningioma growth [6]. Mistakes in the apoptosis mechanism are present meningioma cells [7, 8]. …”

Section: Introductionmentioning

confidence: 99%

“…Positive correlation between apoptotic index (AI) and proliferation index (PI) was shown in meningiomas [8]. AI was also found to be a predictor of meningioma recurrence [8].…”

Section: Introductionmentioning

confidence: 99%

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Caspase-3 and Survivin Expression in Primary Atypical and Malignant Meningiomas

Vranic

2013

ISRN Neuroscience

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“…Because mitosin 10 able to supershift the ATF4-DNA complex in EMSA (Fig. 3), the first domain is located between residues 2645 and 3113, which covered the core region critical for kinetochore targeting (40).…”

Section: Interaction Of Atf4 With Mitosin-we Have Previously Shown Thmentioning

confidence: 99%

Mitosin/CENP-F as a Negative Regulator of Activating Transcription Factor-4

Zhou

Wang

Фан

et al. 2005

Journal of Biological Chemistry

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Mitosin/CENP-F is a human nuclear matrix protein with multiple leucine zipper motifs. Its accumulation in S-G 2 phases and transient kinetochore localization in mitosis suggest a multifunctional protein for cell proliferation. Moreover, its murine and avian orthologs are implicated in myocyte differentiation. Here we report its interaction with activating transcription factor-4 (ATF4), a ubiquitous basic leucine zipper transcription factor important for proliferation, differentiation, and stress response. The C-terminal portion of mitosin between residues 2488 and 3113 bound to ATF4 through two distinct domains, one of which was a leucine zipper motif. Mitosin mutants containing these domains were able to either supershift or disrupt the ATF4-DNA complex. On the other hand, ATF4, but not ATF1-3 or ATF6, interacted with mitosin through a region containing the basic leucine zipper motif. Moreover, overexpression of full-length mitosin repressed the transactivation activity of ATF4 in dual luciferase-based reporter assays, while knocking down mitosin expression manifested the opposite effects. These findings suggest mitosin to be a negative regulator of ATF4 in interphase through direct interaction.

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Meningioma

The Genetics and Molecular Biology of Neural Tumors

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Untitled

Cited by 18 publications

References 27 publications

Caspase-3 and Survivin Expression in Primary Atypical and Malignant Meningiomas

Caspase-3 and Survivin Expression in Primary Atypical and Malignant Meningiomas

Mitosin/CENP-F as a Negative Regulator of Activating Transcription Factor-4

Meningioma

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