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Abildinova, Gulshara; Кулешов, Н. П.; Svyatova, Gulnara

doi:10.1023/a:1025391109169

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…In the present study, considering entirely the studied cohort, a mean frequency of Dic + CR of 0.84 (±0.83) per 1000 cells was found. This value is very similar to other published data on Kazakhstan control subjects reported in previous studies ( Table 3 ) [ 19 , 22 , 23 , 26 , 27 , 33 ]. In particular, a mean dicentric frequency of 0.71‰ was found in a group of control subjects from Kurchatov in northeast Kazakhstan [ 19 ], while a dicentric frequency of 0.78‰ was found in a group of controls from Kokpekty in East Kazakhstan [ 27 ].…”

Section: Discussionsupporting

confidence: 92%

“…To do it, an important prerequisite is to determine the level of the background frequency of dicentrics from healthy people who have not been exposed. Therefore, the starting point in the dose assessment of irradiated people is the determination of the background level of dicentrics, since the baseline level of spontaneous dicentrics can vary significantly in different populations [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study

Kenzhina

Mamyrbayeva

Лукашенко

et al. 2022

IJERPH

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Kazakhstan is known as a country with a complex radioecological situation resulting from different sources such as a natural radiation background, extensive activities of the industrial system of the former Soviet Union and a well-known testing of nuclear power weapons occurred in the Semipalatinsk Test Site (STS) area. The present study focuses on the assessment of the background of dicentric chromosomes in Kazakhstan’s population, which is the starting point in the dose assessment of irradiated people, since the baseline level of spontaneous dicentrics can vary significantly in different populations. In this context, aiming to determine the background frequency of chromosome aberrations in the population of Kazakhstan, considering the heterogeneity of natural radiation background levels of its large territory, a selection of 40 control subjects living in four cities of North, South, West and East Kazakhstan was performed. The cytogenetic study on the selected groups showed fairly low background frequency values of chromosome aberrations (0.84 ± 0.83 per 1000 cells), comparable with other data in the literature on general populations, reporting background frequency values between 0.54 and 2.99 per 1000 cells. The obtained results should be taken into account when constructing the dose–effect calibration curve used in cytogenetic biodosimetry, as a “zero” dose point, which will reduce the uncertainty in quantifying the individual absorbed dose in emergency radiological situations.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study

Kenzhina

Mamyrbayeva

Лукашенко

et al. 2022

IJERPH

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“…The findings of this study demonstrate that the morbidity structure in the long-term period for the cohort of patients exposed to specific causal factors, such as IR and stressful military conflict situations, significantly differs from general population indicators. While cardiovascular diseases (arterial HT, coronary heart disease) are also prominent, cerebrovascular diseases are more prevalent, often manifesting in severe forms (second- to third-degree DEP) with frequent complications, such as strokes [ 29 - 31 ]. A distinctive feature of this cohort is the relatively high frequency of peripheral vascular lesions, multifocal atherosclerosis, and thyroid pathology.…”

Section: Discussionmentioning

confidence: 99%

Comorbid Conditions in Persons Exposed to Ionizing Radiation and Veterans of the Soviet–Afghan War: A Cohort Study in Kazakhstan

Sarkulova,

Tatayeva,

Urazalina

et al. 2024

JPMPH

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Objectives: This study investigated the prevalence and characteristics of comorbid conditions in patients exposed to ionizing radiation and those who were involved in the Soviet–Afghan war.Methods: This study analyzed the frequency and spectrum of morbidity and comorbidity in patients over a long-term period (30-35 years) following exposure to ionizing radiation at the Semipalatinsk nuclear test site or the Chornobyl nuclear power plant, and among participants of the Soviet–Afghan war. A cohort study, both prospective and retrospective, was conducted on 675 patients who underwent comprehensive examinations.Results: Numerical data were analyzed using the Statistica 6 program. The results are presented as the mean±standard deviation, median, and interquartile range (25-75th percentiles). The statistical significance of between-group differences was assessed using the Student t-test and Pearson chi-square test. A p-value of less than 0.05 was considered statistically significant. We found a high prevalence of cardiovascular diseases, including hypertension (55.0%) and cardiac ischemia (32.9%); these rates exceeded the average for this age group in the general population.Conclusions: The cumulative impact of causal occupational, environmental, and ultra-high stress factors in the combat zone in participants of the Soviet–Afghan war, along with common conventional factors, contributed to the formation of a specific comorbidity structure. This necessitates a rational approach to identifying early predictors of cardiovascular events and central nervous system disorders, as well as pathognomonic clinical symptoms in this patient cohort. It also underscores the importance of selecting suitable methods and strategies for implementing treatment and prevention measures.

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Cytogenetic abnormalities of the descendants of permanent residents of heavily contaminated East Kazakhstan

Chaizhunusova

Madiyeva

Tanaka

et al. 2017

Radiat Environ Biophys

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More than 400 nuclear explosion tests were conducted at the Semipalatinsk Nuclear Test Site (SNTS) and significant radioactive substances were released. The long-term consequences of the activities at the SNTS and the appearance of any hereditary effects remain insufficiently studied about 25 years after the test site was closed. The population living in villages near the SNTS are considered to have been heavily exposed to external and internal radiation. This study aims to perform an assessment and comprehensive cytogenetic analysis of the inhabitants living near the SNTS, and their first-(F1) and second-(F2) generation children. Residents of the East Kazakhstan region living in the area covered by the former SNTS were included in the study. To evaluate the hereditary effects of nuclear testing, comprehensive chromosome analyses were performed in lymphocytes using conventional Giemsa and fluorescent in situ hybridization methods in 115 F1 and F2 descendants in the villages of Dolon and Sarzhal, which were heavily contaminated. The parents of the subjects had permanently lived in the villages. A higher number of stable-type chromosome aberrations such as translocations was found in these residents than in 80 residents of the control area, Kokpecty, which indicates the possibility that radiation had biological effects on the exposed subjects.

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Cited by 4 publications

References 5 publications

Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study

Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study

Comorbid Conditions in Persons Exposed to Ionizing Radiation and Veterans of the Soviet–Afghan War: A Cohort Study in Kazakhstan

Cytogenetic abnormalities of the descendants of permanent residents of heavily contaminated East Kazakhstan

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