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Кравченко, Л В; Morozov, Sergey; Beketova, N A; Deryagina, V. P.; Avren'eva, L I; Tutelyan, V A

doi:10.1023/a:1024608730471

Cited by 16 publications

(6 citation statements)

References 8 publications

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“…It can be hypothesized that the decrease in tripeptide concentration is related to activation of glutathione S-transferase. Similar changes were revealed in the cytosolic fraction of rat liver homogenates after 2 weeks of treatment with DHQ in a dose of 130 mg/kg [3].…”

Section: Resultssupporting

confidence: 72%

“…Recent studies showed that DHQ has no genotoxic activity [1]. Most studies of biological activity (e.g., antioxidant properties) were performed in vitro on model systems [3,4,8,9]. Little is known about in vivo properties [3,10] and long-term effect of DHQ [2].…”

mentioning

confidence: 99%

“…Most studies of biological activity (e.g., antioxidant properties) were performed in vitro on model systems [3,4,8,9]. Little is known about in vivo properties [3,10] and long-term effect of DHQ [2]. Some studies have focused on chemiluminescence assay of the antioxidant properties in biological samples or antioxidant enzyme activity.…”

mentioning

confidence: 99%

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Peroxidation Processes in Rats during the Delayed Period after Chronic Administration of Dihydroquercetin

Chernyak

Shchukina

2009

Bull Exp Biol Med

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Peroxidation processes in male outbred albino rats were studied 1, 2, and 3 months after 90-fold administration of dihydroquercetin in doses of 86, 860, and 3000 mg/kg and flavonoid rutin (reference preparation) in a dose of 86 mg/kg. Dihydroquercetin in a dose of 86 mg/kg was as potent as rutin in modulating the process of peroxidation. Changes in the nonenzymatic antioxidant system and activation of lipid peroxidation were not observed in the delayed period after administration of dihydroquercetin.

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Section: Resultssupporting

confidence: 72%

mentioning

confidence: 99%

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Peroxidation Processes in Rats during the Delayed Period after Chronic Administration of Dihydroquercetin

Chernyak

Shchukina

2009

Bull Exp Biol Med

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“…Many studies [29,30] have suggested that lycopene is not detectable in the liver of animals consuming a normal diet without lycopene supplementation. However, lycopene supplementation causes a dose-dependent accumulation of lycopene in liver tissue, which was similar to our results.…”

Section: Discussionmentioning

confidence: 99%

Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils

Choi

Seo

2013

Nutr Res Pract

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The effect of lycopene supplementation on the antioxidant system was investigated by analyzing lipid peroxide levels, glutathione contents, and antioxidant enzyme activities in Mongolian gerbils fed a high fat diet. Gerbils were fed on each experimental diet for 6 weeks; normal diet (NC), normal diet with 0.05% lycopene (NL), high fat diet (HF), and a high fat diet with 0.05% lycopene (HFL). Dietary supplementation of lycopene increased hepatic lycopene level in gerbils fed a normal or high fat diet (P < 0.05). Liver and erythrocyte concentrations of lipid peroxide increased in gerbils fed a high fat diet, whereas lycopene supplementation decreased liver and erythrocyte concentrations of lipid peroxide (P < 0.05). Hepatic total glutathione content was higher in the NL group than that in the NC group (P < 0.05). Total antioxidant status in plasma increased following lycopene supplementation compared with that of the non-lycopene supplemented groups (P < 0.05). Hepatic catalase activity increased following dietary lycopene supplementation (P < 0.05). Superoxide dismutase activity in liver remained unchanged with lycopene supplementation, but erythrocyte superoxide dismutase activity increased in NL group compared with NC group (P < 0.05). Glutathione-S-transferase activity increased in the NL group compared to NC group (P < 0.05). Liver and erythrocyte glutathione peroxidase activity increased significantly in the NL group compared to that in the HF group (P < 0.05). Liver glutathione reductase activity was higher in the NL group than that in the NC group (P < 0.05). These results suggest that lycopene supplementation may be efficient for preventing chronic diseases induced by oxidative stress related to high fat diet.

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“…Previous studies showed that intake of tomatoes and tomato products strengthened the antioxidant system, and inhibited lipid peroxidation in humans [12]. Besides, it was demonstrated that oral lycopene administration for 2 weeks inhibited lipid peroxidation in the liver tissues of rats [13]. The objective of present study was to investigate the protective effect of lycopene on the development of steatohepatitis in NASH model induced by HFD.…”

Section: Introductionmentioning

confidence: 94%

Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet

Bahçecıoğlu

Kuzu

Metin

et al. 2010

Veterinary Medicine International

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We investigated the preventive effect of lycopene on nonalcoholic steatohepatitis-induced by high-fat diet in rats. Forty male Sprague-Dawley rats were divided into 4 groups. They were fed standard diet, high-fat diet (HFD), high-fat diet plus lycopene at a dose of 2 mg/kg body weight and the high-fat diet lycopene at a dose of 4 mg/kg BW for a period of 6 weeks. Inflammation, steatosis, α-smooth muscle actin (α-SMA), and cytochrome P450 2E1 (CYP 2E1) expression increased significantly in the rats fed HFD and decreased in the rats administered by lycopene. Significantly elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor (TNF α), and serum and liver malondialdehyde (MDA) were observed in rats fed the high-fat diet as compared to the control rats (P < .01). Supplementation with lycopene lowered serum MDA and tumor necrosis factor (TNF-α) levels and elevated liver GSH level (P < .001). Insulin resistance was higher in the rats fed HFD than in rats supplemented with lycopene. The data indicate that supplementation with lycopene can reduce high-fat diet-induced oxidative stress to the cells.

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Cited by 16 publications

References 8 publications

Peroxidation Processes in Rats during the Delayed Period after Chronic Administration of Dihydroquercetin

Peroxidation Processes in Rats during the Delayed Period after Chronic Administration of Dihydroquercetin

Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils

Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet

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