Untitled

Shi, Huaiqiu; Farber, Leon; Michaels, James N.; Dickey, Allison N.; Thompson, Karen; Shelukar, Suhas; Hurter, Patricia; Reynolds, Scott; Kaufman, Michael J.

doi:10.1023/a:1022676709565

Cited by 60 publications

(13 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…AFM is widely used for studying of thin polymer and oligopeptides films, drugs and other crystalline compounds to determine the size and shape of crystallites. [ 30 31 32 33 ] Results obtained in the present work are in agreement with the earlier results for different PEGs which showed a low roughness of the surface of the films of this polymer. [ 34 35 ] Low roughness indicates a smoothness of the individual polymer film which allows determining the presence and sizes of crystallites and nanoparticles in the PEG-1000 film.…”

Section: Discussionsupporting

confidence: 92%

A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy

Usmanova

Зиганшин

Gorbatchuk

et al. 2017

J Adv Pharm Technol Res

View full text Add to dashboard Cite

A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of such drugs could be a useful approach to addressing this problem because they combine targeted delivery and good solubility. In this work, the distribution of superparamagnetic nanoparticles in the solid dispersion of polyethylene glycol with average molecular weight 950–1050 g/mol and phenacetin was studied using atomic force and magnetic force microscopy. The distribution of nanoparticles was found to be uniform in studied composites. Magnetically active solid dispersions may find application in the production of the capsulated drug delivery systems with enhanced solubility parameters.

show abstract

Section: Discussionsupporting

confidence: 92%

A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy

Usmanova

Зиганшин

Gorbatchuk

et al. 2017

J Adv Pharm Technol Res

View full text Add to dashboard Cite

show abstract

“…4,5) Shi et al reported the image of drug nanocrystals in the formulation by atomic force microscopy and complementary techniques. 8) They showed the morphology of nanocrystals, though the surface states of the nanocrystals were not well characterized.…”

mentioning

confidence: 99%

Morphology and Surface States of Colloidal Probucol Nanoparticles Evaluated by Atomic Force Microscopy

Moribe

Wanawongthai

Shudo

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Morphology and surface states of colloidal probucol nanoparticles after dispersion of probucol/polyvinylpyrrolidone (PVP)/sodium dodecyl sulphate (SDS) ternary ground mixture into water were investigated by atomic force microscopy (AFM). The observed particles had core-shell structure, i.e. drug nanocrystals were covered with PVP and SDS complex. The AFM phase image and the force curve analyses indicated that probucol nanoparticles with PVP K17 showed layer structure, compared to those with PVPK12. The structural difference was explainable in terms of the molecular states of PVP-SDS complex on the particle surface. These findings support not only the mechanism of drug nanoparticle formation but also the in vivo absorption results with the almost same particle size of ca. 40 nm.Key words atomic force microscopy; colloidal nanoparticle; surface state; grinding; probucol Co-grinding, where a drug is ground together with excipients, is a promising method for an effective reduction of particle size. A certain number of studies revealed that the coground mixture enhanced dissolution, resulting in the improvement of oral absorption and bioavailability.1-3) Wet cogrinding method has been known as an effective method to produce stable nanosuspensions.4-7) Liversidge and Cundy proposed a preparation method for crystalline nanoparticle by wet co-grinding of danazol with polyvinylpyrrolidone (PVP).4) Oral absorption of poorly water-soluble drugs in nanocrystal form was remarkably improved. 4,5) Shi et al. reported the image of drug nanocrystals in the formulation by atomic force microscopy and complementary techniques. 8)They showed the morphology of nanocrystals, though the surface states of the nanocrystals were not well characterized.Compared with the wet co-grinding method, the dry cogrinding process has some advantages for solid pharmaceutical applications due to its simple preparation with free solvents. Our previous studies demonstrated that drug nanoparticle was successfully produced by the dry co-grinding of a poorly water-soluble drug with PVP and sodium dodecyl sulfate (SDS).9-11) When probucol, which is mainly used as a cholesterol-lowering agent, was used as a model drug, solidstate 13 C-NMR studies revealed that the nanoparticle formation and stabilization were attributable to grinding-induced solid-state interactions among components of the drug/ PVP/SDS ternary system.12) The agglomeration of colloidal nanoparticles after dispersing the ground mixture (GM) into water was effectively inhibited in the presence of PVP and SDS. The results of particle size and zeta-potential measurements suggested that the adsorption of both PVP and SDS as the complex on the surface of crystalline particles stabilized the drug nanoparticles.13) Because surface states of the probucol nanoparticles certainly affected the dissolution and the subsequent absorption, the direct observation of the nanoparticles in aqueous environment was an urgent requisite. We have observed the morphology of probucol nanoparticles in water by environm...

show abstract

“…The non-conducting samples like polymeric nano-materials, micro-crystals, etc. can be easily characterized by this approach that is the main advantage of this technique [57].…”

Section: Characterization Approach/ Techno- Logies For Nanosuspensionmentioning

confidence: 99%

Nanosuspension Technology: Recent Patents on Drug Delivery and their Characterizations

Goel¹,

Sachdeva²,

Agarwal³

2019

DDF

View full text Add to dashboard Cite

Background: Nanosuspension has arisen as a remunerative, lucrative as well as a potent approach to improve the solubility and bioavailability of poorly aqueous soluble drug entities. Several challenges are still present in this approach which need more research. The prime aim of this review is to identify such challenges that can be rectified in the future.Methods: Through this review, we enlighten the recent patents and advancement in nanosuspension technology that utilize the different drug moieties, instruments and characterization parameters.Results: Nanosuspension has been found to possess great potential to rectify the several issues related to poor bioavailability, site-specific drug delivery, dosing frequency, etc. In the past decade, nanosuspension approach has been complementarily utilized to solve the developed grievances, arisen from poorly soluble drugs. But this field still needs more attention to new discoveries.Conclusion: Nanosuspension contributes a crucial role in administering the different drug entities through a variety of routes involving oral, transdermal, ocular, parenteral, pulmonary, etc. with solving the different issues. This review also confirms the significance of nanosuspension in safety, efficacy, and communal as well as the economic expense associated with healthcare.

show abstract

Untitled

Cited by 60 publications

References 7 publications

A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy

A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy

Morphology and Surface States of Colloidal Probucol Nanoparticles Evaluated by Atomic Force Microscopy

Nanosuspension Technology: Recent Patents on Drug Delivery and their Characterizations

Contact Info

Product

Resources

About