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Berti, Irene; Trevisiol, Chiara; Tommasini, Alberto; Città, A.; Neri, Elena; Geatti, Onelio; Giammarini, Alberto; Ventura, Alessandro; Not, Tarcisio

doi:10.1023/a:1005441400107

Cited by 71 publications

(11 citation statements)

References 24 publications

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“…None of the other 5 coeliacs identified in our antibody screening had typical or atypical symptoms of coeliac disease. Unlike the previous report [11], we did not find other associated autoimmune diseases in our 7 patients with Hashimoto’s thyroiditis and coeliac disease. It must be, however, underlined that 2 of them, being still fairly young (aged 30 years or less), are likely to develop such a complication later on, and 2 of them, being males, are at a lower risk of multiple autoimmune syndrome.…”

Section: Discussioncontrasting

confidence: 99%

“…Our study confirms the high prevalence of coeliac disease among patients with autoimmune thyroiditis with a slightly lower frequency (3.2%) than that reported in four previous studies including patients with both autoimmune thyroiditis and Graves’ disease (mean value 3.9%) [9, 10, 11, 12]. For the first time, IgA anti-tTG antibodies have been assessed in a large series of patients with autoimmune thyroiditis, giving better results than IgA EmA, which has been considered the best standardised test for coeliac disease screening up to now.…”

Section: Discussionsupporting

confidence: 90%

“…An increased prevalence of coeliac disease has been found in patients with autoimmune thyroiditis and Graves’ disease [9, 10, 11, 12]. Moreover, it has been demonstrated that many coeliacs are affected by autoimmune thyroid dysfunction [2, 4, 5, 8].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, a lower prevalence of coeliac disease in patients with autoimmune thyroid diseases has been demonstrated. Collin et al [9]detected 4 coeliacs (4.8%) among 83 subjects with autoimmune thyroid dysfunction (2 of 52 patients with Graves’ disease and 2 of 31 with autoimmune thyroiditis), whereas the finding of gluten-sensitive enteropathy in these patients, reported more recently by 3 Italian groups, was 3.3, 3.4 and 4.3%, respectively, with a more frequent detection in patients with autoimmune thyroiditis than Graves’ disease [10, 11, 12]. All these studies have been carried out by means of IgA antiendomysial antibodies (EmA), universally recognised as the well-standardised marker with the highest predictive value for coeliac disease [13].…”

Section: Introductionmentioning

confidence: 99%

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Coeliac Disease in Patients with Autoimmune Thyroiditis

et al. 2001

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Background and Aims: The close association between coeliac disease and autoimmunity prompted us to perform an antibody screening for gluten-sensitive enteropathy in patients with autoimmune thyroid dysfunction. Methods: Sera from 220 patients with autoimmune thyroiditis, 50 euthyroid subjects with thyroid nodules and 250 blood donors were tested for IgA anti-tissue transglutaminase (anti-tTG) and antiendomysial antibodies (EmA). Results: IgA anti-tTG was positive in 7 patients with autoimmune thyroiditis, whereas IgA EmA was found only in 6 of them. Duodenal biopsy confirmed coeliac disease diagnosis disclosing marked and mild villous atrophy in 6 and 1 of them, respectively. All but 2 of the 7 coeliacs did not show any sign of malabsorption. All euthyroid controls were negative for IgA antibodies, whereas 1 blood donor, positive for both IgA anti-tTG and EmA, was found to be coeliac. The prevalence of coeliac disease in patients with autoimmune thyroiditis (3.2%) was significantly higher than that found in blood donors (0.4%) (p = 0.022, Fisher’s exact test). Conclusions: Antibody screening for coeliac disease should be included in the work-up of patients with autoimmune thyroiditis. Either IgA anti-tTG or EmA may be used, even though the former seems to be slightly more sensitive than the latter.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Coeliac Disease in Patients with Autoimmune Thyroiditis

et al. 2001

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“…Previous studies reported that the frequency of CD in adults with AT varies from 3.2% to 3.4% [10][11][12][13]. Guliter et al [14] reported the prevalence of CD in adult Turkish patients with AT to be 5.9%.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Celiac Disease in Turkish Children with Autoimmune Thyroiditis

et al. 2008

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The close association between celiac disease (CD) and autoimmune disorders is well documented in adult and pediatric patients. The aim of this study is to determine the prevalence of CD in Turkish children with autoimmune thyroiditis (AT). Sera from 101 children with AT (11 boys and 90 girls, from 2 to 18 years of age; mean age 12.28 +/- 3.26 years) and 103 healthy children (46 boys and 57 girls, from 3.5 to 17 years of age; mean age 12.18 +/- 3.11 years) were screened for CD using the IgA anti-tissue transglutaminase (IgA anti-tTG) antibody and total serum IgA. Small intestinal biopsy was offered to all antibody-positive patients. IgA anti-tTG was positive in eight children (7.9%) with AT. None of the serum samples of healthy children were positive for IgA anti-tTG antibody. Selective IgA deficiency was not detected in patients or controls. Intestinal biopsy was accepted by seven patients. In five patients (4.9%), subtotal villous atrophy was found. These findings indicate that the prevalence of CD is higher in Turkish children with AT than in healthy controls. Routine screening for CD should be performed in children with AT.

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Guideline for the Diagnosis and Treatment of Celiac Disease in Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

Hill,

Dirks,

Liptak

et al. 2005

J. pediatr. gastroenterol. nutr.

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Celiac disease is an immune‐mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals. It occurs in children and adolescents with gastrointestinal symptoms, dermatitis herpetiformis, dental enamel defects, osteoporosis, short stature, delayed puberty and persistent iron deficiency anemia and in asymptomatic individuals with type 1 diabetes, Down syndrome, Turner syndrome, Williams syndrome, selective immunoglobulin (Ig)A deficiency and first degree relatives of individuals with celiac disease. The Celiac Disease Guideline Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition has formulated a clinical practice guideline for the diagnosis and treatment of pediatric celiac disease based on an integration of a systematic review of the medical literature combined with expert opinion.The Committee examined the indications for testing, the value of serological tests, human leukocyte antigen (HLA) typing and histopathology and the treatment and monitoring of children with celiac disease. It is recommended that children and adolescents with symptoms of celiac disease or an increased risk for celiac disease have a blood test for antibody to tissue transglutaminase (TTG), that those with an elevated TTG be referred to a pediatric gastroenterologist for an intestinal biopsy and that those with the characteristics of celiac disease on intestinal histopathology be treated with a strict gluten‐free diet. This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition on the diagnosis and treatment of celiac disease in children and adolescents.

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Untitled

Cited by 71 publications

References 24 publications

Coeliac Disease in Patients with Autoimmune Thyroiditis

Coeliac Disease in Patients with Autoimmune Thyroiditis

Prevalence of Celiac Disease in Turkish Children with Autoimmune Thyroiditis

Guideline for the Diagnosis and Treatment of Celiac Disease in Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

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