148. Synthetic antimalarials. Part IX. 4-Arylamino-2-aminoalkylamino-6-methylpyrimidines. Further variations

Curd, F. H. S.; Davis, Michaël I.; Owen, E. C.; Rose, F. L.; Tuey, G. A. P.

doi:10.1039/jr9460000720

Cited by 2 publications

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“…Substituted pyrimidines were described early as antiplasmodial compounds [6][7][8][9][10][11][12]. Some 2-aminopyrimidines were reported to be active in low micromolar to submicromolar concentration [13].…”

Section: Introductionmentioning

confidence: 99%

New 2-aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities

et al. 2020

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Novel 2-aminopyrimidine derivatives were prepared from acyclic starting materials, benzylidene acetones and ammonium thiocyanates, via 5 steps, including ring closure, aromatization, S-methylation, oxidation to methylsulfonyl compounds, and formation of guanidines with suitable amines. The prepared compounds differ from each other by the substitutions of their amino group and of their phenyl ring. The 2-aminopyrimidines were tested by use of microplate assays for their in vitro activities against a causative organism of sleeping sickness, Trypanosoma brucei rhodesiense, as well as against a causative organism of malaria, Plasmodium falciparum NF54. Their cytotoxic properties were determined with L-6 cells (rat skeletal myoblasts). Some of the compounds exhibited quite good antitrypanosomal activity, and others showed excellent antiplasmodial activity. The influence of the structural modifications on these activities is discussed. Graphic abstract

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