148. Auditory and Visual EEG Validators of Psychosis Biotypes, Findings From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium

Parker, David A.; Trotti, Rebekah; McDowell, Jennifer E.; Keedy, Sarah K.; Sweeney, John A.; Gershon, Elliot S.; Pearlson, Godfrey D.; Keshavan, Matcheri S.; Tamminga, Carol A.; Clementz, Brett A.

doi:10.1016/j.biopsych.2018.02.166

Cited by 3 publications

(3 citation statements)

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“…We did find evidence that entrainment of gamma rhythm in response to steady-state visual stimulation is stronger in patients with depressive symptoms. While our study was not designed to distinguish first-episode affective psychosis from first-episode non-affective psychosis and we emphasize that diagnosis often changes during and after a first episode of psychosis we nonetheless note that our finding is in agreement with a small, but growing, body of evidence that beta and/or gamma SSVEP responses may be different in patients with schizophrenia compared to patients with other psychotic illnesses (Parker et al, 2018). However, we note that our finding was specific for the Depression symptom factor and not for diagnosis.…”

Section: Discussionsupporting

confidence: 84%

Decreased peak alpha frequency and impaired visual evoked potentials in first episode psychosis

Murphy

Öngür

2019

NeuroImage: Clinical

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Abnormal spontaneous and evoked oscillations have been reported in several studies of patients with psychotic disorders. Resting alpha power and peak alpha frequency may be decreased in patients with psychosis. We used high-density EEG (hd-EEG) to record resting-state data and steady-state visual evoked potentials (SSVEPs) in patients with first episode psychosis (FEP) and healthy controls to compare brain resonances across multiple frequencies. We recorded hd-EEG (128 channels) from 22 FEP patients and 22 healthy controls during eyes-closed resting state and eyes-closed photic stimulation at 1 Hz, 4 Hz, 10 Hz, 20 Hz, and 40 Hz. Alpha power, peak alpha frequency, and SSVEP amplitude were analyzed using ANOVA and statistical non-parametric mapping. We found that FEP patients had lower peak alpha frequencies (9.72 Hz vs 10.40 Hz, p = .02, Cohen's d = 0.73) and this decrease was driven by slowing over the central and posterior scalp. There was no difference in alpha power. Alpha waves propagated primarily from anterior to posterior and that propagation was slowed in patients. During SSVEP, patients had smaller increases in EEG power in the stimulation band (F (1,184) = 5.3, p = .02). Patients had attenuated responses to SSVEP stimulation at alpha, beta and gamma frequencies. The gamma response was partially preserved in patients who also had depressive symptoms. We conclude that even in early stages of illness, psychotic disorders are associated with decreased alpha peak frequency and impaired evoked resonances. These findings implicate multiple patterns of dysconnectivity in cortico-cortico and cortico-thalamic networks in FEP.

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Section: Discussionsupporting

confidence: 84%

Decreased peak alpha frequency and impaired visual evoked potentials in first episode psychosis

Murphy

Öngür

2019

NeuroImage: Clinical

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“…31 The Bipolar-Schizophrenia Network on Intermediate Phenotypes has data on thousands of individuals. 32 What these biomarkers lack in accumulated history, they make up in rigorous and explicit validation studies. 17,18 It is thus worth comparing the logic of biomarker development to what goes on in the head of a clinical neurophysiologist reading a single EEG.…”

Section: Clinical Readinessmentioning

confidence: 99%

Section: Clinical Readinessmentioning

confidence: 99%

Neurobehavioral Biomarkers: An EEG Family Reunion

Ewen

Levin

2021

Journal of Clinical Neurophysiology

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The field of clinical EEG has had an uneasy relationship with the use of this technology for clinical cognitive applications and often for good reason. However, apart from its clinical use, EEG has had a tradition as a major tool in cognitive psychology and cognitive neuroscience dating back at least to the 1960s. Based on accumulated knowledge from its research application, EEG-based biomarkers are beginning to see applications in clinical trials and may eventually enter clinical care. We address concerns surrounding quality control, the treatment of artifact, and normal variants and how developments in engineering, biomarker validation, and implementation science rigorously applied to these tools can lead to well-justified approaches.

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Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data

Dickie,

Ameis,

Boileau

et al. 2024

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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148. Auditory and Visual EEG Validators of Psychosis Biotypes, Findings From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium

Cited by 3 publications

References 0 publications

Decreased peak alpha frequency and impaired visual evoked potentials in first episode psychosis

Decreased peak alpha frequency and impaired visual evoked potentials in first episode psychosis

Neurobehavioral Biomarkers: An EEG Family Reunion

Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data

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