148 Age and Sex as Determinants of the Pulmonary Vascular (Pv)response to Chronic Hypoxia in Rats

Abstract

C h i l d r e n ' s H o s p i t a l , Department o f P e d i a t r i c s (C a r d i o l o q v) , Houston The e f f e c t i v e and sa& dosage o f d i g o x i n f o r premature i n f a n t s has n o t y e t been e s t a b l i s h e d. W e compared t h e d i g o x i n serum l e ve l , change i n l e f t v e n t r i c u l a r s y s t o l i c time i n t e r v a l (LVSTI) and t o x i c r r~a n i f e s t a t i o n s i n 2 qroups of premature i n f a n t s , administ e r i n g a t o t a l d i g i t a l i z i n g dose (TDD) o f 30pg/kq t o Gp.1 and a