1474P Immune-inflammatory indexes and BMI as predictors of outcome and treatment response in advanced gastric cancer receiving ramucirumab-containing second-line

Abstract

defined in literature were evaluated in this study. These were: neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), monocyte lymphocyte ratio (MLR), systemic immune-inflammation index (SII), haemoglobin, lymphocyte, platelet. The patients were divided in two subgroups according to the median values of NLR, PLR, MLR and SII.Results: A total of 105 patients with AGC were included in the study. There was no relationship between survival and anaemia (hgb <12gr / dl), thrombocytopenia (100.000 / mL), leukopenia (<4000 / mL) and lymphopenia (1000 / mL) (P ¼ 0.29, P ¼ 0.49, P ¼ 0.53, P ¼ 0.29, respectively). There was a statistically significant relationship between NLR (P ¼ 0.008), PLR (P ¼ 0.019), MLR (P ¼ 0.06) and overall survival; there was no significant result with SII (P ¼ 0.375). While the median survival was 14.6 months in the patients in the low NLR group, this rate was 7.9 months in the high group. Likewise, in the group with low PLR and MLR, the mean survival of the patients was 12.7 and 14.6 months, respectively. Median survival in patients with high PLR and MLR was 8.2 and 7.9 months, respectively. Multivariate analysis showed that NLR was an independent predictor of overall survival.Conclusions: Through the parameters derived from complete blood count, NLR appears to be a promising prognostic marker in patients with AGC.