147 Mr. Matthews to S.P.

Matthews, John; Heath, Helen Truesdell

doi:10.1093/oseo/instance.00005977

Cited by 2 publications

(4 citation statements)

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“…In general, sterilization by the use of steam or chemicals could have unfavorable effects, such as material degradation and cytotoxic action, on medical-grade polymers. 18 In recent years, high-energy irradiation, such as UV irradiation, electron beam radiation, and c irradiation, have been found to be suitable for sterilization in biomedical applications. When polyurethane is exposed to UV irradiation, there is a deterioration of its crystallinity.…”

Section: Introductionmentioning

confidence: 99%

“…21,22 This method is advantageous because c irradiation not only has a strong ability to penetrate materials but is also economically feasible for the large-scale sterilization of products in sealed packages. 18,23 In addition to killing bacteria, c irradiation may produce changes in the bulk polymer; this results in the formation of additional polar groups on the surface, which seems to increase the hydrophilicity and adhesion of cells to the polymer matrix. This effect on the surface significantly improves the biocompatibility of polyurethane contacted with tissues.…”

Section: Introductionmentioning

confidence: 99%

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Effects of wide‐range γ‐irradiation doses on the structures and properties of 4,4′‐dicyclohexyl methane diisocyanate based poly(carbonate urethane)s

Zhang

Jiang

Zhao

et al. 2014

J of Applied Polymer Sci

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For medical applications, 4,4 0 -dicyclohexyl methane diisocyanate (HMDI)-based poly(carbonate urethane)s were synthesized from HMDI and 1,4-butanediol as hard segments and poly(carbonate diol) (number-average molecular weight 5 2000 g/mol) as soft segments. The effects of wide-range c irradiation on the samples were examined through a series of analytical techniques. Scanning electron microscopy revealed that c irradiation etched and roughened the surfaces of the irradiated samples. The gel content and crosslinking density measurements confirmed that crosslinking occurred along with degradation at all of the investigated irradiation doses and the degree of both crosslinking and degradation increased with increasing irradiation dose. Fourier transform infrared spectroscopy demonstrated that chain scission in the c-irradiated samples occurred at the carbonate and urethane bonds. The decreasing molecular weight and tensile strength indicated that the degradation increased with the c-irradiation dose. Differential scanning calorimetry and dynamic mechanical thermal analysis indicated that c irradiation had no significant effect on the phase-separation structures. There was a slight reduction in the contact angle. An evaluation of the cytotoxicity demonstrated the nontoxicity of the nonirradiated and irradiated polyurethanes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of wide‐range γ‐irradiation doses on the structures and properties of 4,4′‐dicyclohexyl methane diisocyanate based poly(carbonate urethane)s

Zhang

Jiang

Zhao

et al. 2014

J of Applied Polymer Sci

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“…[12,13] The autoclave sterilization method, also known as steam sterilization, uses temperatures in the range of 121-134 8C and a humidity of 100% to create conditions in which bacterial spores have low resistance to heat. [14] Though such conditions can also affect materials, a change in the corrosion and mechanical behavior is possible. [15,16] Sterilization using ionizing radiation, also called gamma sterilization, utilizes the biocidal efficacy of ionizing radiation.…”

mentioning

confidence: 99%

“…The emitted radiation destroys the micro organism's deoxyribonucleic acid (DNA) which leads to biological cell death. [14] Premnath et al [17] as well as Jahan et al [18] have shown that the gamma sterilization method can also influence the oxidation behavior of a material and with it the material's properties.…”

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confidence: 99%

The Effect of Different Sterilization Methods on the Mechanical Strength of Magnesium Based Implant Materials

et al. 2011

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The research on the development and characterization of potential magnesium biomaterials is a steadily expanding. Commonly, implants present a high risk of infection for their recipients. For this reason, a pre‐operative sterilizing process is required. Due to the temperatures and media which are used while sterilizing, effects may occur which cause a change in the mechanical strength of certain magnesium alloys. Four commonly used sterilization methods (autoclave sterilization, dry heat sterilization, gamma sterilization and ethylene oxide sterilization) were investigated to gain information about their influences on the quasi‐static mechanical behavior of LAE442 (Mg 90 m.%, Li 4 m.%, Al 4 m.%, RE 2 m.%), MgCa0.8 (Mg 99.2 m.%, Ca 0.8 m.%) magnesium alloys as well as pure magnesium. The mechanical properties exhibited by the sterilized and non‐sterilized alloys refer to susceptibilities of the mechanical strengths to the investigated sterilization methods. Such susceptibilities appear to be dependent on the combination of alloy and method of sterilization. However, the maximum changes in mechanical strength appear in the range of ±10%. Within this study, ETO sterilization caused the least changes in the mechanical strength of the alloys and appears to be the best performer.

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147 Mr. Matthews to S.P.

Cited by 2 publications

References 0 publications

Effects of wide‐range γ‐irradiation doses on the structures and properties of 4,4′‐dicyclohexyl methane diisocyanate based poly(carbonate urethane)s

Effects of wide‐range γ‐irradiation doses on the structures and properties of 4,4′‐dicyclohexyl methane diisocyanate based poly(carbonate urethane)s

The Effect of Different Sterilization Methods on the Mechanical Strength of Magnesium Based Implant Materials

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