Abstract:Background Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of less than 10%, [1][2][3] which is due in part to its dense desmoplastic and immunosuppressive stroma, caused by cancer-associated fibroblasts (CAFs). [4][5][6] T cell function has been extensively explored in many cancers; however, natural killer (NK) cells of the innate immune system are relatively understudied in PDAC. Interestingly, we have previously shown that fibroblasts express known NK cell ligands and hypothesized that CA… Show more
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