1433 Vitamin D Deficiency and Secondary Hyperparathyroidism in Obese Children

Abstract

AbstractsAim of the work To determine the extent and severity of the aforementioned obesity-related atherosclerotic risk factors among school aged children and adolescents. Subjects and methods The sample has included 98 obese (nonsyndromic) and 36 non obese control subjects aged 6-16 years. A questionnaire was filled to evaluate the daily and weekly PA calculated in hours, anthropometry was done and blood pressure was measured, together with assessment of serum lipid profile and levels of fasting blood sugar, ALT, UA, E-selectin and hs CRP. Results 55% of obese group have shown 4 or 5 atherosclerotic RFs. One or more features of abnormal lipid profile were found in 94% of obese group with 73% showing high cholesterol level. ALT and UA were significantly higher in the obese group, similarly E-selectin that was elevated in71% of obese and hs CRP were significantly higher among obese. FBS did not show similar significant elevations. Positive correlations were found between cholesterol, E-selectin and hs CRP with BMI and waist/hip ratio. Conclusion Most of obese children and adolescents do suffer from some risk factors that can lead to an earlier and greater risk for developing atherosclerosis.

Obesity in young children and its relationship with diagnosis of asthma, vitamin D deficiency, iron deficiency, specific allergies and flat‐footedness: A systematic review and meta‐analysis

“…Studies that reported serum levels in nmol L −1 were less uniform, with deficiency cut‐offs ranging from <17.5 to <30 nmol L −1 51,55 (see Table 2). Two of the studies included in the meta‐analysis had a high risk of bias 46,48 . When these studies were removed during sensitivity analysis, the pooled effect size was reduced to OR 1.7 (95% CI 1.3–2.3).…”

“…Of the 27 028 studies identified following database searches and de‐duplication, 41 met the inclusion criteria (Figure 1). These studies presented results investigating relationships between childhood obesity and five distinct health outcomes: asthma ( n = 16), 31–45 vitamin D deficiency ( n = 10), 46–55 iron deficiency ( n = 10), 34,56–64 flat‐footedness/pes planus ( n = 4) 65–68 and allergies ( n = 4) 34,39,69,70 . Two of the studies identified reported results for more than one of the outcomes.…”

“…Nine separate studies were included in the meta‐analysis of vitamin D deficiency and obesity, 46–48,50–55 resulting in a pooled odds ratio of 1.9 (95% CI 1.4–2.5) (Figure 4). The studies showed moderate heterogeneity ( I 2 = 58%).…”

“…With vitamin D levels mediated by sunlight exposure, 47 this could potentially explain the differences observed in children with obesity from a behavioural perspective. Therefore, the results of a number of included studies that did not control for these covariates should be interpreted with caution 46,48,50–53,55 . In the case of iron deficiency, while mechanisms explaining effects of obesity on the condition are not fully understood, individuals with obesity have both increased iron requirements (secondary to increased blood volume) and reduced iron absorption (secondary to increased inflammation) 92 .…”

Vitamin D Deficiency in Children and Adolescents: Role of Puberty and Obesity on Vitamin D Status

“… 34 , 35 Moreover, there are evidences that vitamin D supplementation may prevent obesity. 32 , 35 …”